POSSIBILITIES FOR CORRECTION OF CONDITIONING AND MOTOR COORDINATION PROBLEMS IN OSTEOSARCOPENIA, BY USING DIETARY SUPPLEMENTS WITH CALCIUM AND VITAMINS D3 AND Bb


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Abstract

Objective. To evaluate the effectiveness of a new comprehensive osteosarcopenia treatment program using the biologically active additive Osteomed Forte (OF) containing calcium and vitamins D3 and B6 from its effect on skeletal muscle strength and volume, coordination abilities, motor activity, and social activity levels in older age group patients with osteosarcopenia. Subjects and methods. The investigation enrolled 78 men and postmenopausal women aged 50 to 80 years who had a high risk of fractures, as well as decreased muscle strength, as evidenced by tension dynamometry. Before beginning the rehabilitation cycle, the patients were randomized into 2 groups: 1) 39 patients were prescribed OF for 12 months (a study group); 2) 39 patients who did not receive additional therapy for osteoporosis (a control group). The patients of both groups underwent an examination including bone densitometry, tension dynamometry on a Back-Check device (Dr. Wolff, Germany), functional tests evaluating conditioning and coordination motor abilities, as well as quality of life (QOL) assessment using the QUALEFFO-41 questionnaire. Results. A prospective follow-up study showed that at 12 months the study group had higher back extensor and flexor strength levels (p<0.05). The control group patients exhibited negative changes in the strength of the lateral trunk flexors (p<0.05); following one year, the strength of the flexors and right lateral flexors was significantly lower than that in the study group patients (p < 0.05). Within 12 months, in both groups the functional tests revealed no changes in their mean values, except for worse results of the one-leg standing with the eyes open test in the control group (p < 0.05). Analyzing the changes in QOL indicators after 12 months, the scores for «Pain», «Daily activity», «Mobility», «General health», «Mental status» and «General indicator» were significantly lower (better QOL) in the study group than in the control group (p<0.05). Conclusion. The investigation results showed that the complex dietary supplement OF containing calcium citrate, vitamin D3, and HDBA organic complex with vitamin Be prevents decreases in muscle strength, balance function, and QOL in patients who have osteosarcopenia and a high risk of fractures.

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About the authors

L. A Marchenkova

National Medical Research Center for Rehabilitation and Balneology, Ministry of Health of Russia

Email: MarchenkovaLA@nmicrk.ru
Candidate of Medical Sciences Moscow

E. V Makarova

National Medical Research Center for Rehabilitation and Balneology, Ministry of Health of Russia

Moscow

References

  1. Oliver D., Daly F., Martin F.C. et al. Risk factors and risk assessment tools for falls in hospital in-patients: a systematic review. Age Ageing. 2004; 33: 122-30. doi: 10.1093/ageing/ afh017
  2. Schwendimann R., Buhler H., De Geest S. et al. Characteristics of hospital inpatient falls across clinical departments. Gerontology. 2008; 54: 342-8. doi: 10.1159/000129954
  3. Haines T., Kuys S.S., Morrison G. et al. Balance impairment not predictive of falls in geriatric rehabilitation wards. J Gerontol A Biol Sci Med Sci. 2008; 63: 523-8. DOI: 10.1093/ gerona/63.5.523
  4. So Young Kim, Joon Kyu Lee, Songyong Sim. Hearing impairment increases the risk of distal radius, hip, and spine fractures: A longitudinal follow-up study using a national sample cohort. PLoS One. 2018; 13 (2): e0192820. DOI: 10.1371/ journal.pone.0192820
  5. Volpi E., Nazemi R., Fujita S. Muscle tissue changes with aging. Curr Opin Clin Nutr Metab Care. 2004; 7 (4): 405-10. doi: 10.1097/01. mco.0000134362.76653.b2
  6. Wolfson L., Judge J., Whipple R. et al. Strength is a major factor in balance, gait, and the occurrence of falls. J Gerontol A Biol Sci Med Sci. 1995; 50: 64-7. doi: 10.1093/gerona/50a.special_issue.64
  7. Tinetti M.E., Williams C.S. Falls, injuries due to falls, and the risk of admission to a nursing home. N Engl J Med. 1997; 337: 1279-84. DOI: 10.1056/ NEJM199710303371806
  8. Staggs V.S., Mion L.C., Shorr R.I. Assisted and unassisted falls: different events, different outcomes, different implications for quality of hospital care. Jt Comm J Qual Patient Saf. 2014; 40: 358-64. doi: 10.1016/S1553-7250(14)40047-3.
  9. AIHW, Pointer S. 2015. AIHW PS Trends in hospitalised injury, Australia: 1999-00 to 2012-13. Injury research and statistics series no. 95. Cat. no. INJCAT 171. Canberra: AIHW, 2015.
  10. Endo I., Inoue D., Mitsui T. et al. Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology. 2003; 144: 5138-44. doi: 10.1210/en.2003-0502
  11. Trovato F.M., Castrogiovanni P., Szychlinska M.A. et al. Impact of Western and Mediterranean Diets and Vitamin D on Muscle Fibers of Sedentary Rats. Nutrients. 2018; 10 (2): 231. doi: 10.3390/nu10020231
  12. Burton E., Lewin G., O’Connell H. et al. Falls prevention in community care: 10 years on. Clin IntervAging. 2018; 13: 261-9. doi: 10.2147/CIA.S153687
  13. Hill K.D., Suttanon P., Lin S.-I. et al. What works in falls prevention in Asia: a systematic review and meta-analysis of randomized controlled trials. BMC Geriatr. 2018; 18: 3. doi: 10.1186/s12877-017-0683-1
  14. Kirsti Uusi-Rasi, Pekka Kannus, Saija Karinkanta. Study protocol for prevention of falls: A randomized controlled trial of effects of vitamin D and exercise on falls prevention. BMC Geriatr. 2012; 12: 12. doi: 10.1186/1471-231812-12
  15. Van der Velde R.Y., Brouwers J.R.B.J., Geusens P.P. et al. Calcium and vitamin D supplementation: state of the art for daily practice. Food Nutr Res. 2014; 58 (1). doi: 10.3402/fnr.v58.21796
  16. Papadimitropoulos E., Wells G., Shea B. et al. Meta-analyses of therapies for postmenopausal osteoporosis. VIII: Meta-analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women. Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group. Endocr Rev. 2002; 23 (4): 560-9. doi: 10.1210/er.2001-8002
  17. Boonen S., Lips P., Bouillon R. et al. Need for additional calcium to reduce the risk of hip fracture with vitanin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocr Metab. 2007; 92 (4): 1415-23. doi: 10.1210/jc.2006-1404
  18. Papaioannou A., Kennedy C.C., Giangregorio L. et al. A randomized controlled trial of vitamin D dising strategies after acute hip fracture: no advantage of loading doses over daily spplentation. BMC Musculoskelet Disord. 2011; 12: 135. DOI: 101186/1471-2474-12-135
  19. Hirani V., Cumming R.G., Naganathan V. Longitudinal Associations Between Vitamin D Metabolites and Sarcopenia in Older Australian men: The Concord Health and Aging in Men Project. J Gerontol A Biol Sci Med Sci. 2017; 73 (1): 131-8. doi: 10.1093/gerona/glx086
  20. Pfeifer M., Begerow B., Minne H.W. Vitamin D and muscle function. Osteoporos Int. 2002; 3: 187-94. doi: 10.1007/s001980200012
  21. Verlaan S., Maier A.B., Bauer J.M. Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study. Clin Nutr. 2018; 37 (2): 551-7. DOI: 10.1016/j. clnu.2017.01.005
  22. Bruyere O., Cavalier E., Reginster J.Y. Vitamin D and osteosarcopenia: an update from epidemiological studies. Curr Opin Clin Nutr Metab Care. 2017; 20 (6): 498-503. doi: 10.1097/MCO.0000000000000411
  23. Wimalawansa S.J. Non-musculoskeletal benefits of vitamin D. J Steroid Biochem Mol Biol. 2018; 175: 60-81. doi: 10.1016/j.jsbmb.2016.09.016
  24. Aspell N., Lawlor B., O’Sullivan M. Is there a role for vitamin D in supporting cognitive function as we age? Proc Nutr Soc. 2018; 77 (2): 124-34. DOI: 10.1017/ S0029665117004153
  25. Beydoun M.A., Hossain S., Fanelli-Kuczmarski M.T. Vitamin D Status and Intakes and Their Association with Cognitive Trajectory in A Longitudinal Study of Urban Adults. J Clin Endocrinol Metab. 2018; 103 (4): 1654-68. DOI: 10.1210/ jc.2017-02462
  26. Goodwill A.M., Campbell S., Simpson S.Jr. Vitamin D status is associated with executive function a decade later: Data from the Women’s Healthy Ageing Project. Maturitas. 2018; 107: 56-62. doi: 10.1016/j.maturitas.2017.10.005
  27. Лесняк О.М., Никитинская О.А., Торопцова Н.В. и др. Профилактика, диагностика и лечение дефицита витамина D и кальция у взрослого населения России и пациентов с остеопорозом (по материалам подготовленных клинических рекомендаций). Научно-практическая ревматология. 2015; 53 (4): 403-8
  28. Марченкова Л.А., Макарова Е.В. преимущества комбинации кальция и витамина D в профилактике и лечении остеопороза: ренессанс парадигмы. Профилактическая медицина. 2017; 20 (4): 57-62
  29. Джоунс О., Струков В.И. м др. Коморбидный остеопороз: проблемы и новые возможности терапии (Ч. 2). Врач. 2017; 11: 25-8
  30. Макарова Е.В., Марченкова Л.А., Еремушкин М.А. и др. Изменения состава тела и нарушения координации у пациентов с компрессионными переломами тел позвонков на фоне остеопороза. Вестник восстановительной медицины. 2019; 2: 13-20
  31. Марченкова Л.А., Макарова Е.В., Еремушкин М.А. и др. Исследование особенностей дефицита мышечной массы и влияющих на них факторов у пациентов с переломами тел позвонков на фоне остеопороза. Курский научнопрактический вестник «Человеки его здоровье». 2019; 2: 27-38
  32. Tinetti M.E., Williams C.S. Falls, injuries due to falls, and the risk of admission to a nursing home. N Engl J Med. 1997; 337: 1279-84. DOI: 10.1056/ NEJM199710303371806
  33. Morris M.E. Preventing falls in older people. BMJ. 2012; 345: e4919. doi: 10.1136/bmj.e4919
  34. Марченкова Л.А., Макарова Е.В., Васильева В.А. Влияние HDBA органик комплекса с витамином D и кальцием на качество жизни у лиц с высоким риском переломов, проходящих медицинскую реабилитацию. Вестник восстановительной медицины. 2020; 3 (97): 153-9
  35. Марченкова Л.А., Макарова Е.В., Васильева В.А. и др. Влияние базовой терапии кальцием и витамином D3 и В6 на мышечную силу, финкции движения и баланса у пациентов с остеопорозом, проходивших медицинскую реабилитацию. Вопросы курортологии, физиотерапии и лечебной физической культуры. 2020; 97 (1): 25-34

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