DETERMINANTS OF A RISK FOR CHRONIC KIDNEY DISEASE IN DIABETES MELLITUS


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The influence of genetic factors on the risk of chronic kidney disease (CKD) was evaluated in patients with type 2 diabetes mellitus. A significant association was found between CKD and polymorphism of the genes (the products of which play a decisive role in the pathogenesis of renal injury) encoding the production of endothelial vasoactive factors (NOS34 gene) and lipid metabolism factors (APOB gene).

Full Text

Restricted Access

About the authors

O. Vikulova

Endocrinology Research Center, Moscow

Candidate of Medical Sciences

A. Zheleznyakova

Endocrinology Research Center, Moscow

Email: azhelez@gmail.com

V. Nosikov

GosNII Gentika State Genetics Research Center

M. Shestakova

Endocrinology Research Center, Moscow

References

  1. Викулова O.K. Клинико-лабораторные и генетические факторы развития и прогрессирования диабетической нефропатии у больных сахарным диабетом 1 типа. Автореф. дис.. канд. мед. наук. М., 2003.
  2. Железнякова А.В., Викулова О.К., Носиков В.В. и др. Генетические факторы развития хронической болезни почек у больных сахарным диабетом 2 типа // Теор. и практ. соврем. науки. - 2012; 2: 364-8.
  3. Шестакова М.В., Дедов И.И. Сахарный диабет и хроническая болезнь почек. М., 2009.
  4. Hajhosseiny R., Khavandi K., Goldsmith D. Cardiovascular disease in chronic kidney disease: untying the Gordian knot // Int. J. Clin. Pract. - 2013; 67 (1): 14-31.
  5. Johns M. (Jr), Paulus-Thomas J. Purification of human genomic DNA from whole blood using sodium perchlorate in place of phenol // Anal. Biochem. - 1989; 180 (2): 276-8.
  6. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease // Kidney Int. Suppl. - 2013; 3 (1): 1-150.
  7. Noiri E., Satoh H., Taguchi J. et al. Association of eNOS Glu298Asp polymorphism with end-stage renal disease // Hypertension. - 2002; 40 (4): 535-40.
  8. Shestakova M., Vikulova O., Gorashko N. et al. The relationship between genetic and haemodynamic factors in diabetic nephropathy (DN): Case-control study in type 1 diabetes mellitus (T1DM) // Diabet. Res. Clin. Pract. - 2006; 74 (2): 41-50.
  9. Wang Y., Kikuchi S., Suzuki H. et al. Endothelial nitric oxide synthase gene polymorphism in intron 4 affects the progression of renal failure in non-diabetic renal diseases // Nephrol. Dial. Transplant. - 1999; 14 (12): 2898-902.
  10. Zintzaras E., Papathanasiou A., Stefanidis I. Endothelial nitric oxide synthase gene polymorphisms and diabetic nephropathy: a HuGE review and metaanalysis // Genet. Med. - 2009; 11 (10): 695-706.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2013 Russkiy Vrach Publishing House

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies