GENOTOXICITY ANALYSIS IN MISCARRIAGE


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The performed clinical trial has investigated venous blood genotoxicity indicators (DNA comet level, extracellular DNA, p53 protein level, and leukocyte susceptibility to a prooxidant) in miscarriage.

Full Text

Restricted Access

About the authors

V. Goncharova

N.I. Pirogov Russian National Research Medical University

Email: v_seredenina@mail.ru
Moscow

A. Zhanataev

V.V. Zakusov Research Institute of Pharmacology

Email: v_seredenina@mail.ru
Candidate of Biological Sciences Moscow

Z. Chaika

V.V. Zakusov Research Institute of Pharmacology

Email: v_seredenina@mail.ru
Professor Moscow

A. Durnev

V.V. Zakusov Research Institute of Pharmacology

Email: v_seredenina@mail.ru
MD, Corresponding Member of the Russian Academy of Sciences Moscow

N. Bogdan

V.V. Zakusov Research Institute of Pharmacology

Email: v_seredenina@mail.ru
Moscow

N. Lutsenko

N.I. Pirogov Russian National Research Medical University

Email: v_seredenina@mail.ru
Candidate of Medical Sciences Moscow

K. Morozova

N.I. Pirogov Russian National Research Medical University

Email: v_seredenina@mail.ru
Candidate of Medical Sciences Moscow

S. Lunina

N.I. Pirogov Russian National Research Medical University

Email: v_seredenina@mail.ru
Professor Moscow

Yu. Dobrokhotova

N.I. Pirogov Russian National Research Medical University

Email: v_seredenina@mail.ru
MD; Professor Moscow

O. Makarov

N.I. Pirogov Russian National Research Medical University

Email: v_seredenina@mail.ru
MD; Professor Moscow

References

  1. Макаров О.В. Гинекология. Клинические лекции / М.: ГЭОТАР-Медиа; 2010; 352 с.
  2. Agarwal A., Aponte-Mellado A., Premkumar B. et al. The effects of oxidative stress on female reproduction: a review // Reprod. Biol. Endocrinol. - 2012; 10: 49. doi: 10.1186/1477-7827-10-49
  3. Collins A. Measuring oxidative damage to DNA and its repair with the comet assay // Biochimica et Biophysica Acta (BBA) - General Subjects. - 2014; 1840 (2): 794-800.
  4. Dehua Wei, Qinghua Wu, Huirong Shi. Apoptosis and p53 expression in the placental villi of females with unexplained recurrent spontaneous abortion // Exp. Therap. Med. - 2014; 7: 191-4.
  5. Луценко М.Т., Андриевская И.А. Содержание цитохрома С и количество ядер в состоянии апоптоза в плаценте беременных, перенесших обострение герпес-вирусной инфекции // Фундаментальные исследования. - 2010; 2: 75-9.
  6. Stein T., Scholl T., Schluter M. et al. Oxidative stress early in pregnancy and pregnancy outcome // Free Radical Research. - 2008; 42 (10):841-8.
  7. Hung T., Lo L., Chiu T. et al. A longitudinal study of oxidative stress and antioxidant status in women with uncomplicated pregnancies throughout gestation // Reprod. Sci. - 2010; 17 (4): 401-9.
  8. Slatter T., Park L., Anderson K. et al. Smoking during pregnancy causes double-strand DNA break damage to the placenta // Human Pathology. - 2014; 45 (1): 17-26.
  9. Lim J., Kim M., Han Y. et al. Cell-free fetal DNA and Cell-free total DNA levels in spontaneous abortion with fetal chromosomal aneuploidy // PLoS One. - 2013; 8 (2): 1-8.
  10. Yin A., Ng E., Zhang X. et al. Correlation of maternal plasma total cell-free DNA and fetal DNA levels with short term outcome of first-trimester vaginal bleeding // Hum. Reprod. - 2007; 22: 1736-43.
  11. Clark-Ganheart C., Fries M., Leifheit K. et al. Use of cell-free DNA in the investigation of intrauterine fetal demise and miscarriage // Obstet. Gynecol. -2015; 125 (6): 1321-9.
  12. Zhang J., Zhou F., Song Y. et al. Long Dwell-Time Exposure of human chorionic villi to transvaginal ultrasound in the first trimester of pregnancy induces activation of caspase-3 and cytochrome C release // Biol. Reprod. - 2002; 67: 580-3.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2016 Russkiy Vrach Publishing House

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies