GENOTOXICITY ANALYSIS IN MISCARRIAGE


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The performed clinical trial has investigated venous blood genotoxicity indicators (DNA comet level, extracellular DNA, p53 protein level, and leukocyte susceptibility to a prooxidant) in miscarriage.

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作者简介

V. Goncharova

N.I. Pirogov Russian National Research Medical University

Email: v_seredenina@mail.ru
Moscow

A. Zhanataev

V.V. Zakusov Research Institute of Pharmacology

Email: v_seredenina@mail.ru
Candidate of Biological Sciences Moscow

Z. Chaika

V.V. Zakusov Research Institute of Pharmacology

Email: v_seredenina@mail.ru
Professor Moscow

A. Durnev

V.V. Zakusov Research Institute of Pharmacology

Email: v_seredenina@mail.ru
MD, Corresponding Member of the Russian Academy of Sciences Moscow

N. Bogdan

V.V. Zakusov Research Institute of Pharmacology

Email: v_seredenina@mail.ru
Moscow

N. Lutsenko

N.I. Pirogov Russian National Research Medical University

Email: v_seredenina@mail.ru
Candidate of Medical Sciences Moscow

K. Morozova

N.I. Pirogov Russian National Research Medical University

Email: v_seredenina@mail.ru
Candidate of Medical Sciences Moscow

S. Lunina

N.I. Pirogov Russian National Research Medical University

Email: v_seredenina@mail.ru
Professor Moscow

Yu. Dobrokhotova

N.I. Pirogov Russian National Research Medical University

Email: v_seredenina@mail.ru
MD; Professor Moscow

O. Makarov

N.I. Pirogov Russian National Research Medical University

Email: v_seredenina@mail.ru
MD; Professor Moscow

参考

  1. Макаров О.В. Гинекология. Клинические лекции / М.: ГЭОТАР-Медиа; 2010; 352 с.
  2. Agarwal A., Aponte-Mellado A., Premkumar B. et al. The effects of oxidative stress on female reproduction: a review // Reprod. Biol. Endocrinol. - 2012; 10: 49. doi: 10.1186/1477-7827-10-49
  3. Collins A. Measuring oxidative damage to DNA and its repair with the comet assay // Biochimica et Biophysica Acta (BBA) - General Subjects. - 2014; 1840 (2): 794-800.
  4. Dehua Wei, Qinghua Wu, Huirong Shi. Apoptosis and p53 expression in the placental villi of females with unexplained recurrent spontaneous abortion // Exp. Therap. Med. - 2014; 7: 191-4.
  5. Луценко М.Т., Андриевская И.А. Содержание цитохрома С и количество ядер в состоянии апоптоза в плаценте беременных, перенесших обострение герпес-вирусной инфекции // Фундаментальные исследования. - 2010; 2: 75-9.
  6. Stein T., Scholl T., Schluter M. et al. Oxidative stress early in pregnancy and pregnancy outcome // Free Radical Research. - 2008; 42 (10):841-8.
  7. Hung T., Lo L., Chiu T. et al. A longitudinal study of oxidative stress and antioxidant status in women with uncomplicated pregnancies throughout gestation // Reprod. Sci. - 2010; 17 (4): 401-9.
  8. Slatter T., Park L., Anderson K. et al. Smoking during pregnancy causes double-strand DNA break damage to the placenta // Human Pathology. - 2014; 45 (1): 17-26.
  9. Lim J., Kim M., Han Y. et al. Cell-free fetal DNA and Cell-free total DNA levels in spontaneous abortion with fetal chromosomal aneuploidy // PLoS One. - 2013; 8 (2): 1-8.
  10. Yin A., Ng E., Zhang X. et al. Correlation of maternal plasma total cell-free DNA and fetal DNA levels with short term outcome of first-trimester vaginal bleeding // Hum. Reprod. - 2007; 22: 1736-43.
  11. Clark-Ganheart C., Fries M., Leifheit K. et al. Use of cell-free DNA in the investigation of intrauterine fetal demise and miscarriage // Obstet. Gynecol. -2015; 125 (6): 1321-9.
  12. Zhang J., Zhou F., Song Y. et al. Long Dwell-Time Exposure of human chorionic villi to transvaginal ultrasound in the first trimester of pregnancy induces activation of caspase-3 and cytochrome C release // Biol. Reprod. - 2002; 67: 580-3.

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