Vol 27, No 3 (2016)

A concurrence of dyscirculatory encephalopathy (DE) with diabetic polyneuropathy (DPN), frontal ataxia, vestibulopathy, pyramid syndrome, and blood levels of trace elements in these conditions were studied. An anticomorbidity of DE and DPN was established; the specific features of a profile of the trace elements that are characteristic for each of the neurological disorders were defined. Assessments of risks for the examined abnormalities were given in relation to their clinical presentations, drug intake, diet, and physical activity in patients.

An experiment has investigated the ability of miramistin and chlorhexidine bigluconate, which are immobilized on various bases, to heal purulent wounds. The investigations have shown the advantages of a combination of miramistin and polymethylsiloxane polyhydrate-immobilized chlorhexidine bigluconate with methyluracil over levomecol ointment.

The paper considers the possibilities of a threonine and pyridoxine combination used to treat different central nervous system diseases, as well as Biotredin® to relieve alcohol withdrawal syndrome with a predominance of psychopathological and somatic disorders for disactualization of pathological alcohol craving and for physical and mental stabilization in alcoholics in remission.

Piribedil reduces the degree of major motor symptoms, including the manifestations of motor fluctuations and drug-induced dyskinesia, as well as postural disorders, in Parkinson’s disease.

The efficiency of long-term outpatient treatment with the angiotensin-converting enzyme inhibitor Lisinopril and the vasodilatory α1-, ß1,2 -adrenoblocker carvedilol was studied in patients with coronary heart disease and hypertension who had experienced severe attacks of unstable angina at rest. It was shown that this treatment might substantially slow down the process of ischemic remodeling of the left ventricle (LV), favors regression of its hypertrophy, its better diastolic and systolic function, a lower risk for poor coronary events and progressive chronic heart failure, two-year mortality and ventricular and supraventricular arrhythmia rates.

The paper gives an update on irritable bowel syndrome (IBS). It considers the classification, pathogenesis, and clinical features of IBS with diarrhea, and its treatment options. It is indicated that there is no current effective universal therapy regimen for IBS, which is suited for patients with its different types. Butyrate (Zacofalc) has been observed to have certain success with recent treatment of IBS in order to reduce visceral hypersensitivity and abdominal pain and discomfort. The paper describes methods for evaluating the efficiency of combined therapy with Zacofalc for IBS with diarrhea. It is concluded that incorporation of butyrate (Zacofalc) in the combination therapy of IBS with diarrhea improves quality of life in the patients and enhanced the efficiency of treatment.

In this paper we present the frequency and structure of osteoporotic fractures in women with osteoarthritis according to the constitution. Found that among women with fractures of the constitution mezosomnoy found significantly more often and have a correlation with it. The localization of fractures is also the constitutional relationship. Among women with mezosomy constitution, compared with women with megalosomy constitution is dominated by fractures of the vertebrae, and in patients with megalosomy constitution - fractures of the forearm. Multiple fractures are found only in representatives of mezosomy constitution.

Analysis of vegetative effects on heart rhythm is represented during the appearance of arterial fibrillation paroxysms with patients with ischemic heart disease and arterial hypertension. Gender differences are shown. Prognostic value of time and spectral indices for daily heart rate variability is studied.

Adipokines are potential factors modulating atherogenesis. Their pathogenetic significance was determined in patients with acute myocardial infarction (AMI) and in those with chronic coronary heart disease. Adipokines were established to undergo dynamic changes in AMI, to be involved in the inflammatory responses triggered by ischemia and hemodynamic insufficiency, and to favor the development of insulin resistance, which might suggest that they affected postinfarction remodeling processes in the heart and vessels.

Incorporation of ivabradine at 12 weeks of combination therapy of patients with stable angina concurrent with left ventricular diastolic dysfunction and an ejection fraction of >50% enhances exercise tolerance, alleviates symptoms, and improves quality of life to achieve target heart rate.

The paper discusses combined anticoagulant and antithrombotic therapy (its volume and duration) in a patient with atrial fibrillation after prior myocardial infarction and balloon angioplasty with coronary artery stenting. Therapy to be prescribed should be individually determined for each specific patient.