THE RARE SIDE EFFECT OF BOTULINUM THERAPY IS A VASOSPASTIC REACTION AT THE INJECTION SITES


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The paper describes a rare clinical case of a vasospastic reaction after injection of botulinum toxin type A (BT-A) into the forehead and glabella, as aesthetically indicated. It analyzes the data available in the literature, which describe similar cases, and discusses the possible mechanisms underlying the action of BT-A on vascular tone.

Full Text

Restricted Access

About the authors

A. Sharova

N.I. Pirogov Russian National Research Medical University

Email: aleca@mail.ru
Candidate of Medical Sciences

V. Lysikova

N.I. Pirogov Russian National Research Medical University

References

  1. https://www.surgery.org/sites/default/files/ASAPS-Stats2016.pdf
  2. de Almeida H. Jr., Henkin C., Milman L. et al. Localized flushing absence after abobotulinum toxin A cosmetic treatment // Eur. J. Dermatol. - 2013; 23 (5): 714-5.
  3. Warren D., Woody M., Vickers J. Facial Blanching After Cosmetic Botulinum Toxin Injection: Case Series // Skinmed. - 2016; 14 (3): 239-40.
  4. Khan T., Herne K., Dayan S. et al. Facial blanching due to neurotoxins: proposed mechanisms // Dermatol. Surg. - 2013; 39 (1 Pt. 1): 24-9.
  5. Pomprasit M., Chintrakarn C. Treatment of Frey's syndrome with botulinum toxin // J. Med. Assoc. Thai. - 2007; 90 (11): 2397-402.
  6. Park K., Hyun M., Jeong S. et al. Botulinum toxin for the treatment of refractory erythema and flushing of rosacea // Dermatology. - 2015; 230 (4): 299-301.
  7. Odo M., Odo L., Farias R. et al. Botulinum toxin for the treatment of menopausal hot flushes: a pilot study // Dermatol. Surg. - 2011; 37 (11): 1579-83.
  8. Yuraitis M., Jacob C. Botulinum toxin for the treatment of facial flushing // Dermatol. Surg. - 2004; 30 (1): 102-4.
  9. Eshghi G., Khezrian L., Alirezaei P. Botulinum Toxin A in Treatment of Facial Flushing // Acta Med. Iran. - 2016; 54 (7): 454-7.
  10. Geddoa E., Matar H., Paes T. The use of botulinum toxin-A in the management of neck and anterior chest wall flushing: pilot study // Int. J. Dermatol. - 2013; 52 (12): 1547-50.
  11. Manhäes R., Spitz M., Vasconcellos L. Botulinum toxin for treatment of Harlequin syndrome // Parkinsonism Relat. Disord. - 2016; 23: 112-3
  12. Low D., Hubing K., Del Coso J. et al. Mechanisms of cutaneous vasodilation during the postmenopausal hot flash // Menopause. - 2011; 18 (4): 359-65.
  13. Kellogg D. Jr., Pergola P., Piest K. et al. Cutaneous active vasodilation in humans is mediated by cholinergic nerve cotransmission // Circ. Res. - 1995; 77: 1222-8.
  14. Morris J., Jobling P., Gibbins I. Differential inhibition by botulinum neurotoxin A of cotransmitters released from autonomic vasodilator neurons // Am. J. Physiol. Heart Circ. Physiol. - 2001; 281 (5): H2124-32.
  15. Awan K. The therapeutic usage of botulinum toxin (Botox) in non-cosmetic head and neck conditions - An evidence based review // Saudi Pharm. J. - 2017; 25 (1): 18-24.
  16. Hubing K., Wingo J., Brothers R. et al. Nitric oxide synthase inhibition attenuates cutaneous vasodilation during postmenopausal hot flash episodes // Menopause. - 2010; 17 (5): 978-82.
  17. Reame N. Why fixing the furrow does not fix the flash: understanding hot flash biology with botulinumneurotoxin. Menopause. - 2011; 18 (4): 348-9.
  18. Oh Y., Lee N., Suh D. et al. A split-face study using botulinum toxin type B to decrease facial erythema index // J. Cosmet. Laser Ther. - 2011; 13 (5): 243-8.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2022 Russkiy Vrach Publishing House

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies