Pathogenetic communication of erectile dysfunction, anxiety and depressive disorders in hypertension


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Erectile dysfunction (ED) in patients with arterial hypertension (AH) is very common, reaching according to various authors 70%, with accompanying psychoemotional disorders aggravate the course of sexual as well as somatic disorders. Associated pathology increases the risk of premature death, worsens the prognosis and reduced social functioning of patients. The common pathogenetic mechanisms of ED, anxiety and depressive disorders and hypertension are endothelial dysfunction with decreased nitric oxide, low levels of androgens, the violation of cortico-visceral connections with the imbalance of the hypothalamic-pituitary-adrenal system and sympathicotonia. Complex pathophysiology requires prescription of adequate anti-hypertensive and psychotherapy, effective treatment of erectile dysfunction.

Full Text

Restricted Access

About the authors

E. Petrova

Penza State University

Email: petrovaelena2010@yandex.ru
Associate Professor, Candidate of Medical Sciences

A. Shutov

Ulyanovsk State University

Professor, MD

V. Strukov

Penza Institute for Postgraduate Training of Physicians, Branch, Russian Medical Academy of Continuing Professional Education

Professor, MD

References

  1. Goldstein I. The mutually reinforcing triad of depressive symptoms, cardiovascular disease, and erectile dysfunction // Am. J. Cardiol. 2000; 86 (2): 41-5.
  2. El-Sakka A. Erectile dysfunction, depression, and ischemic heart disease: does the existence of one component of this triad necessitate inquiring the other two? // J. Sex Med. - 2011; 8 (4): 937-40.
  3. Hatzimouratidis K., Eardley I., Giuliano F. et al. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. European Association of Urology Web site. http://uroweb.org/guideline/male-sexual-dysfunction/ Updated 2015.
  4. Lewis R., Fugl-Meyer K., Corona G. et al. Definitions / epidemiology / risk factors for sexual dysfunction // J. Sex Med. - 2010; 7: 1598-607.
  5. Пушкарь Д.Ю., Камалов А.А., Аль-Шукри С.Х. и др. Первое пилотное эпидемиологическое исследование распространенности эректильной дисфункции в Российской Федерации. Эффективная фармакотерапия // Эндокринология. - 2013; 1 (9): 28-31.
  6. Laumann E. et al. Sexual dysfunction in the United States: Prevalence and predictors // JAMA. -1999; 281: 537-44.
  7. Smith D., Frankel S., Yamell J. Sex and death: are they related? Findings from the Caerphilly Cohort Study // BMJ. -1997; 315: 1641-4.
  8. Bach L., Mortimer J., Van de Weerd C. et al. The association of physical and mental health with sexual activity in older adults in a retirement community // J. Sex Med. - 2013; 10 (11): 2671-8.
  9. Gandaglia G., Briganti A., Jackson G. et al. A systematic review of the association between erectile dysfunction and cardiovascular disease // Eur. Urol. -2014; 65: 968-78.
  10. Giuliano F., Leriche A., Jaudinot E. et al. Prevallence of erectile dysfunction among 7689 patients with diabbetes or hypertension, or both // J. Urol. - 2004; 64: 1196-201.
  11. Vlachopoulos C. Definition and Assessment of Erectile Dysfunction. In: M. Viigimaa, C. Vlachopoulos, M.Doumas. Erectile Dysfunction in Hypertension and Cardiovascular Disease / Springer International Publishing, Switzerland, 2015; pp. 9-17.
  12. Clavijo R., Miner M., Rajfer J. Erectile Dysfunction and Essential Hypertension: The Same Aging-related Disorder? // Rev. Urol. - 2014; 16: 167-71.
  13. Blick C., Ritchie R., Sullivan M. Is Erectile Dysfunction an Example of Abnormal Endothelial Function? // Curr. Vasc. Pharmacol. - 2016; 14 (2): 163-7.
  14. La Vignera S., Condorelli R., Vicari E. et al. Arterial erectile dysfunction: reliability of new markers of endothelial dysfunction // J. Endocrinol. Invest. - 2011; 34 (10): 314-20.
  15. Arana Rosainz Mde J., Ojeda M., Acosta J. et al. Imbalanced lowgrade inflammation and endothelial activation in patients with type 2 diabetes mellitus and erectile dysfunction // J. Sex Med. - 2011; 8: 2017-30.
  16. Мontorsi P., Montorsi F., Schulman C. Is erectile dysfuncttion the «tip of the iceberg» of a systemic vascular disorder? // Eur. Urol. - 2003; 44: 352-4.
  17. Vlachopoulos C., Ioakeimidis N, Terentes-Printzios D. et al. Plasma total testosterone and incident cardiovascular events in hypertensive patients // Am. J. Hypertens. - 2013; 26: 373-81.
  18. Novo S., Iacona R., Bonomo V. et al. Erectile dysfunction is associated with low total serum testosterone levels and impaired flow-mediated vasodilation in intermediate risk men according to the Framingham risk score // Atherosclerosis. - 2015; 238 (2): 415-9.
  19. Spitzer M., Basaria S, Travison T. et al. The effect of testosterone on mood and well-being in men with erectile dysfunction in a randomized, placebo-controlled trial // Andrology. - 2013; 1 (3): 475-82.
  20. Lunenfeld B., Mskhalaya G., Zitzmann M. et al. Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men // Aging Male. -2015; 18 (1): 5-15.
  21. Dean J., McMahon C., Guay A. et al. The International Society for Sexual Medicine's Process of Care for the Assessment and Management of Testosterone Deficiency in Adult Men // J. Sex Med. - 2015; 12 (8): 1660-86.
  22. Gathright E., Goldstein C., Josephson R. et al. Depression increases the risk of mortality in patients with heart failure: A meta-analysis // J. Psychosom. Res. -2017; 94: 82-9.
  23. Scalco A., Scalco M., Azul J. et al. Hypertension and depression // Clinics. - 2005; 60 (3): 241-50.
  24. Нуралиева Н.Ф., Напалков Д.А. Депрессия и кардиоваскулярные болезни // Вестн. РАМН. - 2014; 9-10: 21-6.
  25. Fiedorowicz J. Depression and cardiovascular disease: an update on how course of illness may influence risk // Curr. Psychiatry Rep. - 2014; 16 (10): 492.
  26. Finnell J., Wood S. Neuroinflammation at the interface of depression and cardiovascular disease: Evidence from rodent models of social stress // Neurobiol. Stress. - 2016; 4: 1-14.
  27. Atlantis E., Shi Z., Penninx B. et al. Chronic medical conditions mediate the association between depression and cardiovascular disease mortality // Soc. Psychiatry Psychiatr. Epidemiol. - 2012; 47 (4): 615-25.
  28. Berntson J., Stewart K., Vrany E. et al. Depressive symptoms and selfreported adherence to medical recommendations to prevent cardiovascular disease: NHANES 2005-2010 // Soc. Sci. Med. - 2015; 138: 74-81.
  29. Piepoli M., Hoes A., Agewall S. et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR) // Eur. Heart J. - 2016; 37 (29): 2315-81.
  30. Мамедов М.Н. Проблемы мужского здоровья в кардиологической практике. 2 изд. / М.: Кардиопрогресс, 2014.
  31. Chrysant S. Antihypertensive therapy causes erectile dysfunction // Curr. Opin. Cardiol. - 2015; 30 (4): 383-90.
  32. Al Khaja K., Sequeira R., Alkhaja A. et al. Antihypertensive Drugs and Male Sexual Dysfunction: A Review of Adult Hypertension Guideline Recommendations // J. Cardiovasc. Pharmacol. Ther. - 2016; 21 (3): 233-44.
  33. DeLay K., Haney N., Hellstrom W. Modifying Risk Factors in the Management of Erectile Dysfunction: A Review // World J. Mens Health. - 2016; 34 (2): 89-100.
  34. Nehra A., Jackson G., Miner M. et al. The Princeton III consensus recommendations for the management of erectile dysfunction and cardiovascular disease // Mayo Clin. Proc. - 2012; 87: 766-78.
  35. Yuan J., Zhang R., Yang Z. et al. Comparative effectiveness and safety of oral phosphodiesterase type 5 inhibitors for erectile dysfunction: a systematic review and network meta-analysis // Eur. Urol. - 2013; 63: 902.
  36. Калинченко С.Ю., Тюзиков И.А., Ворслов Л.О. и др. Эректильная дисфункция: парадоксы и парадигмы современной патогенетической фармакотерапии // Сonsilium Мedicum. - 2014; 16 (1): 78-82.
  37. Петрова Е.В., Вакина Т.Н. Терапевтическая коррекция уровня дегидроэпиандростеронасульфата и тестостерона при сексуальных дисфункциях // Врач. - 2014; 1: 60-1.
  38. Петрова Е.В., Вакина Т.Н., Бурмистрова Л.А. Сексуальные дисфункции при тревожно-депрессивных расстройствах // Лечащий врач. - 2014; 5: 108-11.
  39. Petrova E., Shutov A. Therapeutic correction testosterone deficiency in hypertensive men with erectile dysfunction and depression // J. Sex Med. - 2016; 13 (5, Suppl. 2): 146.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies