Vol 29, No 7 (2018)

Ischemic stroke (IS) is a complex multifactorial disease with a now widely discussed polyfactor hereditary component and biochemical, metabolic, inflammatory, coagulation, and hemodynamic factors. Its development is also influenced by environmental conditions. The assessment of the contribution of various risk factors to the prognosis of a first and recurrent IS can serve as the basis for developing personalized programs for primary and secondary IS prevention, especially in high-risk group patients. The issues of primary and secondary stroke prevention are common for neurologists, cardiologists, endocrinologists, therapists, and, of course, general practitioners.

Organic solvents commonly used in various production activities are organic substances and compounds, which are characterized by a variety of chemical structures and physical properties. Long-term uncontrolled exposure to organic solvents can cause a variety of chronic lesions of many organs and systems of the body.

The paper describes current views on the pathogenesis of metabolic syndrome and its correlation with skin abnormality, such as psoriasis. It indicates the relationship between insulin resistance and the severity of the psoriatic process. There are data on the management of patients with metabolic syndrome and psoriasis: the design of a follow-up and the recommendations for lifestyle and combination therapy.

The innovative drug Polyhemostat has been designed and patented by Russian scientists and registered by the Ministry of Health of the Russian Federation. The drug has been undergone pre- and post-registration clinical studies in a number of leading Russian clinics and military hospitals. The paper considers the experience in topically applying Polyhemostat.

The paper describes a clinical case of the differential diagnosis of local Wegeneds granulomatosis in a patient with long-term drug immunosuppression..

The paper describes a rare clinical case of a patient with pyoderma gangrenosum. It discusses the etiology, pathogenesis, clinical presentations, and differential diagnosis of this disease and principles of its treatment.

The incorporation of zinc sulfate into the standard treatment regimen for peptic duodenal bulb ulcer can eliminate immunological shifts occurring in this pathology and results in an increase in the peripheral blood levels of leukocytes, lymphocytes, Tlymphocytes, and B lymphocytes and a decrease in the blood levels of IgM, circulating immune complexes, and the proinflammatory cytokine tumor necrosis factor-α.

Osteoarthritis (OA) is one of the most common joint diseases. The problem of its treatment needs to form the new approaches meeting the high safety requirements, especially in elderly people with comorbidity. A patient group of 72 people aged 38 to 76 years with a reliable diagnosis of OA and long-standing severe pain syndrome was selected. Thirty-two patients received treatment with ionized gel with hyaluronic acid and transcranial electrostimulation sessions, resulting in a reduction in pain by 56% of the baseline value on the visual analog scale, which was 2.3 times higher than that in the control group (24.3%). Upon completion of a 10-session cycle, the dose of used nonsteroidal anti-inflammatory drugs (NSAIDs) was reduced by 2 times in 58% of cases in the study group; 10% of patients completely discontinued the drugs; 4 weeks later only 25% of patients resumed taking NSAIDs at an average therapeutic dose. The use of ionized hyalurone-containing gel and transcranial electrical stimulation in patients with chronic pain syndrome in OA can be a promising rehabilitation technique at the stage of restorative treatment.

Erectile dysfunction (ED) in patients with arterial hypertension (AH) is very common, reaching according to various authors 70%, with accompanying psychoemotional disorders aggravate the course of sexual as well as somatic disorders. Associated pathology increases the risk of premature death, worsens the prognosis and reduced social functioning of patients. The common pathogenetic mechanisms of ED, anxiety and depressive disorders and hypertension are endothelial dysfunction with decreased nitric oxide, low levels of androgens, the violation of cortico-visceral connections with the imbalance of the hypothalamic-pituitary-adrenal system and sympathicotonia. Complex pathophysiology requires prescription of adequate anti-hypertensive and psychotherapy, effective treatment of erectile dysfunction.

Open femoral fractures are a serious problem of modern traumatology. Various approaches to primary wound debridement and fracture stabilization have been developed. The paper analyzes the experience with delayed external osteosynthesis.