Optimization of diagnostics of urogenital tract infections caused by obligate pathogens in women

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Abstract

Sexually transmitted infections remain an important medical and social problem. Untimely detection and, accordingly, late initiation of treatment lead to chronicity of the infectious-inflammatory process and the development of complications such as infertility.

Purpose. Assess the validity of diagnosing an infectious-inflammatory process based on the results of a microscopic examination - leukocyte reaction.

Material and methods. A retrospective analysis of medical records of 102 women was carried out, the results of microscopic examination, polymerase chain reaction (PCR), and real-time PCR were analyzed.

Results. The clinical picture in patients with obligate pathogens and patients with an inflammatory process caused by opportunistic microorganisms did not differ significantly: slightly and moderately severe clinical symptoms predominated. The infectious-inflammatory process caused by obligate pathogens was accompanied by an increase in the number of polymorphonuclear leukocytes only in 22.73% of cases; in other cases, the pathological process proceeded without a leukocyte reaction.

Conclusion. When diagnosing an infectious-inflammatory process, it is necessary to use not only routine methods, but also screening studies aimed at excluding obligate pathogens.

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About the authors

E. V. Lipova

State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency of Russia

Author for correspondence.
Email: kursld@mail.ru

Professor, MD

Russian Federation, Moscow

Yu. G. Vitvitskaya

State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency of Russia

Email: kursld@mail.ru

Candidate of Medical Sciences

Russian Federation, Moscow

I. I. Glazko

State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency of Russia

Email: kursld@mail.ru

Candidate of Medical Sciences; Associate Professor

Russian Federation, Moscow

E. A. Karasev

State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency of Russia

Email: kursld@mail.ru

Candidate of Medical Sciences

Russian Federation, Moscow

V. N. Volgin

State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency of Russia

Email: kursld@mail.ru

MD

Russian Federation, Moscow

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Supplementary files

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2. Fig. 1. Severity of discharge in the study groups; %

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3. Fig. 2. Structure of complaints in the study groups

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4. Fig. 3. Severity of clinical symptoms in the study groups; %

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5. Fig. 4. Distribution of obligate pathogens depending on lesion localization

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