Vol 23, No 7 (2012)

The paper considers the classification, epidemiology, pathophysiology, diagnosis of extraosseous calcification, and its complications in chronic kidney disease, as well as basic patient management strategies.

The long-term SMILE study project using zofenopril has demonstrated that it is expedient and safe to early use the drug in hemodynamically stable patients with anterior myocardial infarction receiving no thrombolytic therapy and provided evidence that the specific features of individual angiotensin-converting enzyme inhibitors, which are associated with their chemicopharmacological properties, are of clinical value.

Рассматриваются механизмы нарушения минерального гомеостаза у пациентов с хронической болезнью почек (ХБП). Показано, что ранний и эффективный контроль минерально-костного метаболизма как на додиализной стадии, так и при лечении диализом - это ключ к успешному управлению ХБП.

The paper describes the physiological mechanisms of magnesium involvement in the function of different human body systems at the level of a cell and subcellular structures. Magnesium deficiency, the incidence of which in clinical practice is as high as 70% and which appears as cardiovascular, cerebral, visceral, and muscular-tetanic syndromes, shows a clinical diversity. The pathophysiological mechanisms responsible for the implication of magnesium deficiency in the formation of insulin resistance (IR) as a key component of metabolic syndrome (MS) are discussed in detail. The authors present the results of combination treatment incorporating magnesium preparations (Magnerot 3 g/day) in 69 patients with MS. They also give the data of an analysis of the time course of changes in IR values, carbohydrate and lipid metabolic parameters, and blood rheological spectra.

The paper characterizes the irritable bowel syndrome, one of the most common and most complex functional disorders of the gastrointestinal disorders. It gives current approaches to its treatment, including that with psychotropic agents.

Using the data of a review of the medical research literature and their own results of the examination and treatment of patients with a body mass index of ≥2 5 kg/m 2 as the basis, the authors show the negative role of oxidative stress in forming insulin resistance (IR) in early metabolic syndrome (MS). The combination treatment of 54 patients with MS incorporated the antioxidants: 60 mg coenzyme Q 10 + 9 mg vitamin E daily. The study has shown that there is a close correlation between the levels of IR and the markers of oxidative stress. The restored capacity of the antioxidant system (coenzyme Q 10 + vitamin E) promotes the effective recovery of sensitivity of insulin receptors to insulin in the early phases of obesity.

40% of the inhabitants of our country suffer from arterial hypertension. Fixed-dose combination antihypertensive drugs allow the cardiovascular risk to be reduced (by 20-25% for myocardial infarction, 50% for heart failure, and 35-40% for stroke).

It is expedient to evaluate systemic and segmental autonomic tone in biliary dysfunctions, by us-ing the standard CYTO autonomic test. The antidepressant and anxiolytic sulpiride (Prosulpin) enhances quality of life for patients and normalizes an imbalance in the autonomic nervous sys-tem.

The impact of the use of diroton as monotherapy and as part of hormone replacement therapy on the quality of life of the examinees (women with arterial hypertension and hypoestrogenemia in the premenopausal period) was studied.

All our examined smoking patients with respiratory panic disorders had comorbid bronchopulmonary diseases and 75% had their family history. The latter is a basis for the vulnerability of the respiratory system and smoking is a factor that shows evidence of this vulnerability with higher levels of anxiety.

The results of surgical treatment in 159 patients with esophageal cancer were used to analyze the causes of major postoperative complications influencing the occurrence of fatal outcomes in patients undergoing intrapleural esophagoplasty.