Vol 25, No 12 (2014)

The paper gives the results of estimating the capabilities of anthropometric methods and bioimpedance analysis (BIA) in the early diagnosis of malnutrition in patients with chronic renal failure. In patients with edema, BIA is shown to be of more informative value in estimating muscle and fat masses, the integral indices of malnutrition, than anthropometric measurements. The most significant factors for malnutrition and the principles of its prevention are defined in these patients.

Skin is the largest organ of the body and is constantly exposed to physical, chemical, bacterial and fungal challenges. It is well known that probiotics are helpful for specific disorders and different clinical studies have indicated that probiotics have special effects in cutaneous apparatus directly or indirectly which can be considerable from versatile aspects. Probiotic bacteriotherapy and trace elements can have great potentials in preventing and treating the skin diseases including eczema, atopic dermatitis, acne, allergic inflammation or in skin hypersensitivity, UV-induced skin damage, wound protection and cosmetic products. The paper presents a review of the clinical effectiveness of Lactobacillus casei rhamnosus 35-based probiotic in conjunction with zinc and selenium in dermatovenereology.

Coronary heart disease holds leading positions in the structure of cardiovascular morbidity and mortality despite the introduction of myocardial revascularization procedures into clinical practice and the possibilities of standard antianginal therapy. When viewed in these perspectives, it is expedient to assess the role of pharmacological modulation of myocardial metabolic processes in the treatment of patients with stable angina pectoris.

The paper gives an update on jaw osteonecroses occurring with the use of different drugs and considers some diagnostic issues, treatment options, prognosis, and recommendations for the prevention of this disease.

Submitted by clinical observation polidisplasticheskoy rare form of epidermolysis bullosa complicated by secondary amyloidosis with renal impairment and a walk in with chronic renal failure

The presence and pattern of a relationship between parathyroid hormone (PTH), phosphorus and calcium hemostatic parameters, and lymphocyte death were studied in chronic renal failure (CRF) patients on hemodialysis. The relationship between lymphocytopenia in CRF patients and activation of lymphocyte death due to necrosis and apoptosis was laboratorily verified. The higher lymphocyte count in blood flow with the signs of necrosis and apoptosis were proven to increase with the higher plasma concentrations of PTH and phosphates and with the lower levels of total calcium.

Affective spectrum disorders (depressions and anxieties) concurrent with acute coronary syn-drome (ACS) negatively affect its course and prognosis. The authors have studied the impact of anxiety and depressive disorders on the hemostatic system in patients with ACS.

The paper gives the intermediate results of a study analyzing a group of 2078 patients receiving antiviral therapy with Cagocel.

The paper discusses the immunotropic effects of melatonin, which may be related to its action through melatonin receptors on immunocompetent cells and to its activating effect in elaborating cytokines by these cells.

The paper considers the role of trace elements in the etiology and pathogenesis of arrested sexual functional development (ASFD) in adolescents. Attention is drawn to the need to determine the concentration ratio of essential to toxic chemical elements affecting the development of reproductive function. Elevated leptin levels have been found to play a role in the occurrence of ASFD in obese children. A draft scheme is proposed for its etiological diagnosis in boys and correction. Antioxidant trace elements have been substantiated to be of importance for the rehabilitative therapy of ASFD.