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卷 30, 编号 2 (2019)
- 年: 2019
- 文章: 16
- URL: https://journals.eco-vector.com/0236-3054/issue/view/5902
Articles
Russia’s first experience with GLE/PIB for the treatment of HCV infection genotype 3A with cryoglobulinemia and concomitant HBV infection in a hemodialysis patient with CKD C5d awaiting kidney transplantation
摘要
The paper presents Russia’s first case of successful use of a 8-week therapy course using an original interferon-free combination of the third-generation NS3/4A protease inhibitor glecaprevir (GLE) and the second-generation NS5A-replication enzyme inhibitor pibrentasvir (PIB) in clinical practice to treat HCV infection genotype 3A with mixed cryoglobulinemia syndrome and concomitant HBV infection in a patient with chronic kidney disease C5d, who received chronic dialysis after elective bilateral nephrectomy for renal polycystosis and awaited donor kidney transplantation.
Vrach. 2019;30(2):3-13
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Colon dysbiosis and chronic kidney disease
摘要
The colon microbiota was investigated in patients with chronic kidney disease (CKD) and manifestations of renal failure. Colon dysbiosis was detected in all the patients, which was manifested predominantly by the proteolytic flora of enteropathogenic Escherichia coli, Enterobacter spp/Citrobacter spp., and clinically by the symptoms of intestinal dyspepsia (symptoms of tympanism and constipation). The use of Laminolact in CKD patients normalizes the colon microbiota and reduces the manifestations of renal failure.
Vrach. 2019;30(2):14-18
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Pneumoconiosis: view modifications, molecular genetic markers, pharmacotherapy
摘要
There is no specific pathogenetic therapy for dust lung diseases (pneumoconiosis); approaches to symptomatic bronchodilator therapy are described. The issues of prevention and sociomedical examination in these diseases are discussed.
Vrach. 2019;30(2):19-25
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Byssinosis: state-of-the-art
摘要
The paper discusses the current ideas on the causes, clinical presentations, diagnosis, treatment, and prevention of byssinosis and on working capacity examination in patients with this occupational disease.
Vrach. 2019;30(2):26-31
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New possibilities for the treatment of dry eye syndrome in an internist’s practice
摘要
One of the common causes of worse quality of life and disability in the active population of almost all ages is dry eye syndrome (DES), a set of corneal and conjunctival changes caused by systematic tear film destabilization. In some cases DES causes severe changes in the cornea - its irreversible opacities, ulcerations, and even perforation. DES treatment and prevention with drugs that moisturize the ocular surface is the therapy of choice. There are a significant amount of tear substitutes on the market, but when making a choice, it is important to remember about the need for long-term treatment of the ocular surface and the safety of the components of an eye medication.
Vrach. 2019;30(2):32-36
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Multiplex analysis of tumor markers in the early diagnosis of recurrences of ovarian granulosa cell tumors
摘要
Tumor markers for ovarian granulosa cell tumors (OGCT) are an important and integral component of a comprehensive screening program for women in the recovery period after antitumor treatment. At the same time, many issues reflecting the clinical and laboratory significance of tumor markers in the early preclinical diagnosis and prognosis of OGCT recurrences have been studied insufficiently and remain an actual problem of rehabilitation in gynecological cancer patients.
Vrach. 2019;30(2):37-40
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Localized prostate cancer: transcriptional mechanisms of early recurrence
摘要
The author shows that in localized prostate cancer, one of the mechanisms of activation of the transcriptional potential of cancer cells and early recurrence of the disease is to increase the expression of the HIFIa and NF-kB genes in glandular tissue.
Vrach. 2019;30(2):41-43
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Atelectasis: clinical and endoscopic comparisons
摘要
Clinical and endoscopic comparisons were carried out in 156 patients with identified atelectasis. Bronchoscopy showed that 68.6% of cases had atelectasis due to bronchial obturation with a tumor, secretory plug or foreign body; 16.67% of cases were noted to have bronchial compression caused by external compression due to (as brought to light later) peribronchial tumor growth or to have bronchial compression due to enlarged lymph nodes. Bronchoscopy revealed no abnormalities in 14.7% of cases; during treatment these patients were found to have community-acquired pneumonia (12.2%) and infiltrative pulmonary tuberculosis (2.56%).
Vrach. 2019;30(2):44-47
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Echocardiographic features in patients with chronic obstructive pulmonary disease and new-onset tuberculosis
摘要
The concurrence of chronic obstructive pulmonary disease and tuberculosis significantly increases the likelihood of cardiac structural and functional changes, by raising the risk of cardio-vascular disease, which aggravates the course of both the underlying and concomitant diseases.
Vrach. 2019;30(2):48-51
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Impact of a one-month antiretroviral therapy cycle on the serum phospholipid composition in patients with TB/HIV coinfection
摘要
Under the influence of antiretroviral therapy, the digital values of phospholipid fractions in patients with tuberculosis/HIV coinfection approaches the normal levels, which can serve as proof of the validity of this treatment in patients with tuberculosis and HIV infection.
Vrach. 2019;30(2):52-53
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The detection rate and variants of monoclonal gammopathy among patients in a multidisciplinary therapeutic hospital
摘要
Oligosecretory monoclonal gammopathy is the result of the hyperproduction of a small proliferating cell clone, which, after various periods, can transform into overt secreting hematological tumors, but may be a cause of non-tumor organ and tissue damage, including kidney disease. The frequency, severity, and spectrum of monoclonal gammopathy in patients from different departments of a multidisciplinary therapeutic hospital have been studied. The nosological characteristics of diseases associated with monoclonal gamma of undetermined significance (MGUS) are given; special attention is paid to kidney diseases, including immune-mediated diseases, the association of which to MGUS has been least studied.
Vrach. 2019;30(2):54-59
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Systematic review on the short-term efficacy and safety of nicorandil for stable angina pectoris in comparison with those of ß-blockers, nitrates and calcium antagonists
摘要
Nicorandil significantly reducted the incidence of major coronary events in patients with stable angina in a long-term trial, although there are few reports on its short-term efficacy in the treatment and prevention of angina symptoms. We performed a meta-analysis of the short-term efficacy of nicorandil compared with antianginal drugs for stable angina.
Vrach. 2019;30(2):60-66
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Famciclovir in the treatment of herpesvirus infections: new and forgotten pages
摘要
The paper considers the issues of pharmacokinetics and pharmacodynamics of famciclovir in the treatment of herpesvirus infections. Investigations have demonstrated the high efficacy of famciclovir, especially in the treatment of manifestations of herpesvirus infections, accompanied by neurological symptoms, such as pain. It also describes the efficacy of short-cycle famciclovir, which increases patient adherence to treatment and allows the latter to be initiated as soon as possible at the first symptoms of recurrence.
Vrach. 2019;30(2):67-74
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Erythema nodosum: diagnostic issues
摘要
The paper gives the results of studying the features of the clinical picture and diagnosis of erythema nodosum in rheumatologic patients.
Vrach. 2019;30(2):75-78
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Methods for treating vitreous and retinal hemorrhage using recombinant prourokinase in patients with eyeground disease concurrent with diabetic retinopathy, hypertensive retinopathy in type 2 diabetes mellitus
摘要
Today, recombinant prourokinase is an indispensable Russian enzyme preparation in ophthalmology. Gemase, the active ingredient of which is a human recombinant prourokinase, is capable of quickly eliminating massive hemorrhages into the vitreous body, retina and anterior chamber of the eye. The drug is widely used in hemorrhagic forms of diabetic retinopathy, hypertensive retinopathy, and age-related macular degeneration with a hemorrhagic component. It is effective in treating eye injuries, postoperative fibrinoid syndromes, thrombosis of the central retinal vein and its branches, occlusions of the central retinal artery and its branches.
Vrach. 2019;30(2):79-84
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New approaches of modern enterosorption amoung bacterial, viral infections and toxidermia
摘要
The article focuse a modern description of the clinical significance of enterosorption in general clinical practice and the relationship with the microbiota. An analysis of the clinical case of a toxic-allergic reaction and the successful application of Zosterin Ultra sorbent in combination therapy of dysbiosis associated toxicoallergic reactions is presented.
Vrach. 2019;30(2):85-92
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