ENDOCRINE AND METABOLIC CHARACTERISTICS OF PATIENTS WITH DIFFERENT PHENOTYPES OF POLYCYSTIC OVARY SYNDROME
- Authors: CHERNUKHA G.E1, BLINOVA I.V1, KUPRASHVILI M.I1
-
Affiliations:
- Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
- Issue: No 2 (2011)
- Pages: 70-76
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246520
- ID: 246520
Cite item
Open Access
Access granted
Abstract
Objective. To study the endocrine and metabolic characteristics of different phenotypes of polycystic ovary syndrome (PCOS). Subjects and methods. A complete clinical and laboratory study was made in 155 reproductive-age women, including 135 patients with PCOS and 20 healthy individuals. Results. The complete phenotype of PCOS was identified in 63%; its incomplete phenotypes were determined in the other cases; among them, both androgenic and non-androgenic phenotypes were encountered with nearly equal frequency. The patients with the androgenic phenotypes of PCOS, particularly with its complete form, besides hyperandrogenemia, were more frequently found to have elevated luteinizing hormone levels and more significant metabolic disorders than those with the non-androgenic phenotype and with carbohydrate metabolic disturbances being uncharacteristic of them; dyslipoproteinemia was 1.5 times less common and hyperinsulinemia and metabolic syndrome were observed 2 times less frequently. Conclusion. The women with ovulation and hyperandrogenemia have a higher risk for the metabolic disturbances similar to the earlier known phenotypes of PCOS whereas the risks for metabolic syndrome associated with type 2 diabetes mellitus and cardiovascular diseases are low in women having anovulation with hyperandrogenism.
Full Text
About the authors
G. E CHERNUKHA
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
Email: c-galinal@yandex.ru
I. V BLINOVA
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
M. I KUPRASHVILI
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
References
- Altmäe S., Haller K., Peters M. et al. Aromatase gene (CYP19A1) variants, female infertility and ovarian stimulation outcome: a preliminary report // Reprod. Biomed. Online. — 2009. — Vol. 18, № 5. — P. 651— 657.
- Azziz R. Diagnostic criteria for polycystic // Fertil. and Steril. — 2005. — Vol. 83. — P. 1343-1346.
- Azziz R. Diagnosis of polycystic ovarian syndrome: The Rotterdam criteria are premature // J. Clin. Endocrinol. Metab. — 2006. — Vol. 91, № 3. — P. 781-785.
- Azziz R., Carmina E., Dewailly D. et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report // Fertil. and Steril. — 2009. — Vol. 91, № 2. — P. 456-488.
- Barber T.M., Wass J.A., McCarthy M.I., Franks S. Metabolic characteristics of women with polycystic ovaries and oligoamenorrhoea but normal androgen levels: implications for the management of polycystic ovary syndrome // Clin. Endocrinol. (Oxford). — 2007. — Vol. 66. — P. 513-517.
- Belosi C., Selvaggi L., Apa R. et al. Is the PCOS diagnosis solved by ESHRE/ASRM // Hum. Reprod. — 2006. — Vol. 21. — P. 3108-3115.
- Carmina E., Chu M.C., Longo R.A. et al. Phenotypic variation in hyperandrogenic women influences the findings of abnormal metabolic and cardiovascular risk parameters // J. Clin. Endocrinol. Metab. — 2005. — Vol. 90, № 5. — P. 2545-2549.
- Conroy R.M., Pyorala K., Fitzgerald A.P. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project // Eur. Heart J. — 2003. — Vol. 24. — P. 987-1003.
- Eckmann K.R., Kockler D.R. Aromatase inhibitors for ovulation and pregnancy in polycystic ovary syndrome // Ann. Pharmacother. — 2009. — Vol. 43, № 7. — P. 1338—1346.
- Ehrmann D.A. Polycystic ovary syndrome // N. Engl. J. Med. — 2005. — Vol. 352. — P. 1223-1236.
- Hsu M.I., Liou T.H., Chou S.Y. et al. Diagnostic criteria for polycystic ovary syndrome in Taiwanese Chinese women: comparison between Rotterdam 2003 and NIH 1990 // Fertil. and Steril. — 2007. — Vol. 88. — P. 727-729.
- Kauffman R.P., Baker T.E., Baker P. et al. Endocrine and metabolic differences among phenotypic expressions of polycystic ovary syndrome according to the 2003 Rotterdam consensus criteria // Am. J. Obstet. Gynecol. — 2007. — Vol. 198, № 6. — P. 670—677.
- The Rotterdam ESHRE/ASRM sponsored PCOS consensus workshop. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) // Fertil. and Steril. — 2004. — Vol. 81. — P. 19-26.
- Saely C.H., Koch L., Schmid F. et al. Adult Treatment Panel III 2001 but not International Diabetes Federation 2005 criteria of the metabolic syndrome predict clinical cardiovascular events in subjects who underwent coronary angiography // Diabetes Care. — 2006. — Vol. 29, № 4. — P. 901—907.
- Shroff R., Syrop C.H., Davis W. et al. Risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria // Fertil. and Steril. — 2007. — Vol. 88, № 5. — P. 1389—1395.
- Stein K.F., Leventhal M.L. Amenorrhea associated with bilateral polycystic ovaries // Am. J. Obstet. Gynecol. — 1935. — Vol. 29. — P. 181-191.
- Welt C.K., Gudmundsson J.A., Arason G. et al. // Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features // J. Clin. Endocrinol. Metab. — 2006. — Vol. 91. -P. 4842-4848.
- Xita N., Georgiou I., Lazaros L. et al. The synergistic effect of sex hormone-binding globulin and aromatase genes on polycystic ovary syndrome phenotype // Eur. J. Endocrinol. — 2008. — Vol. 158, № 6 — P. 861—865.
- Zawadzki J.K., Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach // Polycystic ovary syndrome. / Eds. Dunaif A. et al. — Boston: Blackwell Scientific, 1992. — P. 377-384.
Supplementary files
