PRACTICE FOR USING ANTIMICROBIAL AGENTS IN WOMEN WITH INFLAMMATORY DISEASES OF SMALL PELVIC ORGANS IN THE RUSSIAN FEDERATION

Objective. To study real clinical practice for using antimicrobial agents to treat inflammatory diseases of small pelvic organs (IDSPO) in the Russian Federation and its conformity with Russian and foreign guidelines. Material and methods. The authors conducted a multicenter retrospective pharmacoepidemiological study that included data on women who had sought medical advice at the out- and inpatient obstetric or gynecological institutions of the Russian Federation in 2007 to 2009. The inclusion criteria were the established diagnosis of acute IDSPO, use of at least one dose of a systemic or local antimicrobial agent in the study period. Results. A total of 1174 primary medical records of patients with acute IDSPO were analyzed. Forty-five different antimicrobial agents from 17 groups were found to be used to treat acute IDSPO. The drugs most commonly prescribed to treat IDSPO were as follows: the physicians prescribed most frequently the following drugs: metronidazole (32.7%), gentamicin (13.1%), doxycycline (5.2%), cefazolin (5.1%), and ciprofloxacin (4.9%). In addition, the study has revealed that the percentage of prescriptions for original drugs and branded and nonbranded generics is 1.7, 33.9, and 64.4%, respectively. Conclusion. The currently most common antimicrobial agents used to treat IDSPO in the Russian Federation are metronidazole (32.7%), gentamicin (13.1%), and doxycycline (5.2%). In Russian real clinical practice, the antibiotic combinations recommended by Russian and foreign scientists are used sporadically (less than 1%).

pharmacoepidemiology, inflammatory diseases of small pelvic organs, antibiotics