CLINICAL MANIFESTATIONS OF POLYCYSTIC OVARY SYNDROME AT A LATE REPRODUCTIVE AGE AND IN POSTMENOPAUSE
- Authors: CHEBOTNIKOVA T.V1,2, DAVYDOVA G.N3, KHOLODOVA Z.L3, ILYIN A.V1, GONCHAROV N.P1, DEDOV I.I1, MELNICHENKO G.A1
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Affiliations:
- Endocrinology Research Center, Ministry of Health and Social Development of Russia
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
- Russian State Medical University, Russian Agency for Health Care
- Issue: No 1 (2012)
- Pages: 64-69
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246700
- ID: 246700
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Abstract
Objective. To def ine age-related changes in the clinical picture of polycystic ovary syndrome (POS). Subjects and methods. The study enrolled 60 POS patients aged over 40 years (38 patients at a late reproductive age and 22 in postmenopause). A control group comprised 197 women (mean age 52.8±7.2 years). All the patients underwent a clinical laboratory examination involving hormonal and biochemical (lipid fractions) studies and an oral glucose tolerance test. Results. TThe POS patients over aged 40 years were not found to have biochemical hyperandrogenism both at a late reproductive age and in menopause; type 2 diabetes mellitus (type 2 DM) and glucose tolerance were detected in a third (n=18) and every five (n=13) of patients, respectively; which is substantially higher than that in the comparison group stratified by body mass index and age. Obesity in POS makes an additional contribution, by increasing the risk of type 2 DM: odds ratio 5.58 (95% confidence interval 1.33-32.69). Conclusion. POS may be considered to be a powerful risk factor for carbohydrate metabolic disturbances. Obesity in POS is an additional risk factor and generally aggravates the course of the disease.
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About the authors
T. V CHEBOTNIKOVA
Endocrinology Research Center, Ministry of Health and Social Development of Russia; Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
Email: t-che@yandex.ru
G. N DAVYDOVA
Russian State Medical University, Russian Agency for Health CareDepartment of Obstetrics and Gynecology, Faculty of Pediatrics
ZH. L KHOLODOVA
Russian State Medical University, Russian Agency for Health CareDepartment of Obstetrics and Gynecology, Faculty of Therapeutics
A. V ILYIN
Endocrinology Research Center, Ministry of Health and Social Development of Russia
N. P GONCHAROV
Endocrinology Research Center, Ministry of Health and Social Development of Russia
I. I DEDOV
Endocrinology Research Center, Ministry of Health and Social Development of Russia
G. A MELNICHENKO
Endocrinology Research Center, Ministry of Health and Social Development of Russia
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