STUDY OF THE HORMONAL PROFILE IN PATIENTS AFTER GYNECOLOGICAL OPERATIONS

Objective. To study the hormonal profile in patients after different gynecological operations. Subjects and methods. Examinations were made in 106 patients who had undergone surgery for tubal pregnancy, ovarian (endometrioid, follicular, corpus luteal) cysts, uterine myoma; of them 35 patients were operated for tubectomy, 40 for ovarian resection, and 31 for conservative myomectomy). The hypothalamic-pituitary system of the patients was studied via enzyme immunoassay of the secretion of gonadotropic and ovarian hormones. The study was conducted before and 1, 3, and 7 days and 1 month following surgery. The patients received combined oral contraceptives (Novynette, Regulon, and Lindynette) from the seventh day. Results. All the patients were observed to have impaired hormonal homeostasis at the level of both pituitary and steroid hormones in the first (1—7) days after surgical treatment. There were no considerable preoperative hormonal changes. Only 20% of the patients operated for tubectomy had normal hormonal homeostastic parameters one month after surgical operations. The most significant changes were seen in a group of patients after ovarian resection — the hormonal homeostatic parameters were in the normal range only in 10% of the patients one month following surgery. Slight changes in the content of the hormones were noted in patients with uterine myoma before and after surgery. Conclusion. By taking into account the degree of hormonal disorders, there is a need for rehabilitation measures, by obligatorily using combined oral contraceptives.

hormonal disorders, ovarian resection, tubectomy, conservative myomectomy