CLINICAL AND MICROBIOLOGICAL RATIONALE FOR COMBINATION THERAPY FOR NONGONOCOCCAL INFLAMMATORY DISEASES OF THE UROGENITAL TRACT IN REPRODUCTIVE-AGED WOMEN


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Objective. To study the clinical and microbiological efficiencies and validity of a comprehensive approach to safocid and hexicon therapy for nongonococcal inflammatory diseases of the female urogenital tract. Material and methods. Real-time polymerase chain reaction, cervical canal discharge microscopy, and microbiocenosis examination were made. The combined drug safocid and the antiseptic hexicon were used in accordance with the manufacturer’s recommendations. Results. Varying combinations of obligate and opportunistic bacteria were found in patients with inflammatory diseases of the urogenital tract. According to the treatment option, the patients were divided into two groups: Group 1 (a basis group) was treated with etiotropic agents; Group 2 used the combined drug safocid and hexicon vaginal suppositories. A comparison group consisted of 30 apparently healthy women. The maximum etiological and microbiological efficiencies were revealed in the combination therapy group. Conclusion. The use of a combination of the combined drug safocid and the antiseptic hexicon for the treatment of inflammatory diseases of the urogenital tract contributes to the normalization of the resident microflora, prevents vaginal colonization with yeast-like fungi, and produces a high etiological cure rate.

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作者简介

O. LETYAEVA

South Ural State Medical University, Ministry of Health of Russia

Email: olga-letyaeva@yandex.ru
Chelyabinsk

I. DOLGUSHIN

South Ural State Medical University, Ministry of Health of Russia

Chelyabinsk

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