Gene polymorphism as a predictor of recurrent pregnancy losses


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Abstract

Objective. To reveal gene polymorphisms in women prone to recurrent miscarriage. Subject and methods. Serum gene polymorphisms were investigated in 100 women. Group 1 consisted of 70 patients with recurrent miscarriage who were divided into subgroups according to the time and genesis of pregnancy losses: 1a) 30 patients with recurrent early losses (at less than 22 weeks of gestation); 1b) 30 patients with very early and early preterm labor (at 22 to 32 weeks of gestation); 1c) 10 patients with a history of antenatal fetal deaths (at more than 22 weeks of gestation). Group 2 (a control group) included 30 patients with uncomplicated pregnancy and a history of at least timely births. Results. There were significant differences in the distribution of the genotypes and alleles of the COL1A1 genes: -1997 C>A (rs1107946), IL15 RA: 364 (361) A>C (rs2296135) in the group of pregnant women with early miscarriage versus the control group; those of the genotypes and alleles of the IL8 genes: -251 A>T (rs4073), FN1: 5349+203 T>C (rs2304573) in the women with a history of early preterm labors; and those of the polymorphic IL1b genes: -31 T>C (rs1143627), IL1b: -511 G>A (rs16944), FN1: 5349+203 T>C (rs2304573), FN1:1819+7 A>T (rs3796123) in the group of women with a history of antenatal fetal deaths versus the control group. Conclusion. Determination of gene polymorphisms when planning pregnancy makes it possible to predict the course of a future pregnancy and to form groups at risk for miscarriage for more careful pregestational preparation and for identification of pregnancy management tactics.

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About the authors

E. V Alegina

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: aleginai@rambler.ru
Graduate student, Department of Pregnancy Loss Prevention and Therapy

N. K Tetruashvili

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tetrauly@mail.ru
MD, Head of the Department of Pregnancy Loss Prevention and Therapy

A. A Agadzhanova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tetrauly@mail.ru
MD, leading researcher of the Department of Pregnancy Loss Prevention and Therapy

D. Yu Trofimov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: d_troflmov@oparina4.ru
PhD in medical sciences, Head of Laboratory of molecular genetic methods

A. E Donnikov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru
PhD in medical sciences, leading researcher of Laboratory of molecular genetic methods

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