The peripheral blood count of regulatory T cells in women and the efficiency of in vitro fertilization


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Abstract

Objective. To reveal a relationship between the levels of regulatory T (T eg) cells in the peripheral blood of patients and the occurrence of conception after in vitro fertilization (IVF). Subject and methods. A prospective pilot study was conducted in 36 tubal infertility patients included in an IVF program. The levels of T eg cells with the CD4 +CD25 highCD127 low/- phenotype in the peripheral blood CD4+ lymphocyte subpopulation were estimated in the patients and the relationship between the count of T cells and the occurrence of conception was analyzed. Results. The count of Treg cells in a group of women who became pregnant was substantially lower (p = 0.0045). ROC analysis (the area under the curve was 0.781) showed that the conception rate was significantly higher when the level of T eg cells was 46.3% (p = 0.0003). Conclusion. The count of T reg cells in the peripheral blood of women is a prognostic factor to estimate the probability of conception in the IVF program.

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About the authors

Marina Arkadyevna Nikolaeva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: nikolaeva_ma@mail.ru
Doctor of Science, Leading researcher, Laboratory of Clinical Immunology

Elena Olegovna Stepanova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: elena2404.07@mail.ru
Junior researcher, Laboratory of Clinical Immunology

Alina Anatolievna Babayan

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: alinababayan@yandex.ru
Graduate student, Department of Assisted Technologies in the Infertility Treatment

Lyudmila Viktorovna Vanko

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: LVanko@oparina4.ru
M.D., Professor, Leading researcher, Laboratory of Clinical Immunology

Veronika Yuryevna Smolnikova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: v_smolnikova@oparina4.ru
M.D., Leading Researcher, Department of Assisted Technologies in the Infertility Treatment

Elena Anatolievna Kalinina

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
Doctor of Science,Head of the Department of Assisted Technologies in the Infertility Treatment

Lyubov Valentinovna Krechetova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: l_krechetova@oparina4.ru
Ph.D. in medical sciences, Head of Laboratory of Clinical Immunology

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