Promises for the comprehensive assessment of clinical and morphological data in the diagnosis and pregravid preparation of patients with chronic endometritis
- Authors: Manukhin I.B.1, Gogsadze I.G.1, Gogsadze L.G.1, Ponomareva Y.N.1
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Affiliations:
- A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
- Issue: No 9 (2014)
- Pages: 98-102
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247303
- ID: 247303
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Abstract
Objective. To enhance the efficiency of the diagnosis and treatment of chronic endometritis via comprehensive analysis of the clinical and morphological data associated with chronic endometrial inflammation and via differentiated choice of pharmacotherapy duringpregravidpreparation. Subject and methods. A complex clinical and morphological examination was made in 30 patients diagnosed as having chronic endometritis. Immunomorphological examination of pipelle endometrial biopsy specimens employed an immunoperoxide technique using primary monoclonal antibodies to immunoglobulins M and G, vascular endothelial growth factor (VEGF), tumor necrosis factor-a (TNF-а), transforming growth factor P } (TGF-в), Ki-67, Вс1-2, Вах, and steroid receptors. Results. Endometrial inflammatory changes were found to be characterized by the presence of plasma cells, lymphoid infiltrates, stromal fibrosis, vascular wall sclerosis, TNF-a and TGF-P } expression, high VEGF, Ki-67, and Bax levels, a lower bcl/Bax ratio, and markedly decreased estrogen and progesterone receptor levels. Conclusion. Preliminary clinical and morphological examination-based combination therapy in patients with chronic endometritis is optimal for conception and for reduction of the number of obstetric and perinatal complications.
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About the authors
Igor Borisovich Manukhin
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Email: katemanu@mail.ru
Doctor of Medicine, Professor, Head of the Department of Obstetrics and Gynecology
Iya Georgievna Gogsadze
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Email: iya_gogsadze@mail.ru
Postgraduate Student, Department of Obstetrics and Gynecology
Liya Georgievna Gogsadze
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Email: iya_gogsadze@mail.ru
Postgraduate Student, Department of Obstetrics and Gynecology
Yuliya Nickolaevna Ponomareva
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Email: Juliyapon@mail.ru
MD, Professor of the Department of Obstetrics and Gynecology
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