Prediction of placental insufficiency in multiple pregnancy, by identifying placental growth factor
- Authors: Barinov S.V.1, Rogova E.V.1, Kadtsyna T.V.2, Shamina I.V.2
-
Affiliations:
- Omsk State Medical Academy
- Omsk State Medical Academy, Ministry of Health of Russia
- Issue: No 7 (2015)
- Pages: 43-47
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247478
- ID: 247478
Cite item
Open Access
Access granted
Abstract
Objective. To improve perinatal outcomes in multiple pregnancy, by predicting gestational complications and elaborating a package of diagnostic and treatment measures in this group of pregnant women. Subjects and methods. A study group consisted of 124 women having a multiple pregnancy who underwent an elaborated system of diagnostic and treatment measures; a comparison group included 126 women having a multiple pregnancy who underwent the standard examination and treatment procedure. A control group comprised 50 women having a single pregnancy. Resu1ts. Examination of serum placental growth factor (PlGF) levels in 124 women with the first trimester (6-8 weeks) of pregnancy with preeclampsia and multiple pregnancy indicated that very low maternal serum PlGF levels (111.5±8.2 μmol/l) favored the development of decompensated placental insufficiency and early miscarriage (r = 0.89; p < 0.01). Conclusion. Based on these markers for endothelial dysfunction, the authors elaborated and introduced a package of diagnostic and treatment measures, which could improve perinatal outcomes and reduce perinatal losses by 1.5 times (14.4% in 2012 to 9.8% in 2014).
Full Text
About the authors
Sergey Vladimirovich Barinov
Omsk State Medical Academy
Email: barinov_omsk@mail.ru
M.D., Associate Professor, head of the chair of Obstetrics and Gynecology № 1
Elena Vladimirovna Rogova
Omsk State Medical Academy
Email: elena_omsk67@mail.ru
Candidate of Medical Science, Assistant of the chair of Obstetrics and Gynecology № 2
Tatiana Vladimirovna Kadtsyna
Omsk State Medical Academy, Ministry of Health of Russia
Email: tatianavlad@list.ru
Candidate of Medical Science, Assistant of the chair of Obstetrics and Gynecology № 2
Inna Vasilievna Shamina
Omsk State Medical Academy, Ministry of Health of Russia
Email: innadocsever@rambler.ru
Candidate of Medical Science, Assistant of the chair of Obstetrics and Gynecology № 2
References
- Фролова О.Г., Егорова О.А. Многоплодная беременность (особенности течения и обследования). Обзор и проблемы беременности. 2000; 2: 1-16. [Frolova O.G., Egorova O.A. Multiple pregnancy (the course and examination). Obzor i problemyi beremennosti. 2000; 2: 1-16. (in Russian)]
- Сичинава Л.Г., Панина О.Б., Калашников С.А., Висаитова М.Б. Монохориальная двойня: особенности течения беременности и родов, перинатальные исходы. Акушерство и гинекология. 2003; 2: 9-13. [Sichinava L.G., Panina O.B., Kalashnikov S.A., Visaitova M.B. Monochorionic twins: the course of pregnancy and perinatal outcomes. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2003; 2: 9-13. (in Russian)]
- Савельева И.В., Баринов С.В., Рогова Е.В. Роль фактора роста плаценты в прогнозе тяжелых гестационных осложнений у беременных с метаболическим синдромом. Российский вестник акушера-гинеколога. 2012; 1: 16-9. [Saveleva I.V., Barinov S.V., Rogova E.V. The role of placental growth factor in the prediction of severe gestational complications in pregnant women with metabolic syndrome. Rossiyskiy vestnik akusheraginekologa. 2012; 1: 16-9. (in Russian)]
- Рогова Е.В., Баринов С.В., Савельева И.В., Долгих Т.И. Значение фактора роста плаценты в генезе осложнений при многоплодной беременности. Российский вестник акушера-гинеколога. 2012; 5: 16-9. [Rogova E.V., Barinov S.V., Saveleva I.V. Dolgih T.I. The value of placental growth factor in the genesis of complications of multiple pregnancy. Rossiyskiy vestnik akushera-ginekologa. 2012; 5: 16-9. (in Russian)]
- Милованов А.П., Кирющенков П.А., Шмаков Р.Г., Оразмурадов А.А., Хубецева М.Т. Плацента - регулятор гемостаза матери. Акушерство и гинекология. 2001; 3: 3-6. 5. [Milovanov A.P., Kiryuschenkov P.A., Shmakov R.G., Orazmuradov A.A., Hubetseva M.T. The placenta - a regulator of hemostasis mother. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2001; 3: 3-6. (in Russian)]
- Отраслевой стандарт. Протокол ведения больных. Профилактика тромбоэмболии легочной артерии при хирургических и иных инвазивных вмешательствах (ОСТ 91500.11.0007-2003). Приказ МЗ РФ от 09.06.2003 г. № 233. М.: Ньюдиамед; 2004. 64с. [Industry Standard. Treatment Protocol. Prevention of pulmonary embolism in surgical and other invasive procedures (OST 91500.11.0007-2003). Order of the Ministry of Health of the Russian Federation of 09.06.2003 № 233. M.: Nyudiamed; 2004. 64 p. (in Russian)]
- Сухих Г.Т., Мурашко Л.Е., ред. Преэклампсия. Руководство. М.: ГЭОТАР-Медиа; 2010. 586с. [Suhih G.T., Murashko L.E., red. Preeclampsia. Guide. M.: GEOTAR-Media; 2010. 586 p. (in Russian)]
- Barillari G., Albonici L., Franzese O., Modesti A., Liberati F., Barillari P. et al. The basic residues of placenta growth factor type 2 retrieve sequestered angiogenic factors into a solube form:implications for tumor angiogenesis. Am. J. Pathol. 1998; 152(5): 1161-6.
Supplementary files
