Current aspects of combination antibiotic therapy for nonspecific vaginitis and cervicitis: Results of the noninterventional study Balance


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Abstract

Objective. To evaluate the efficacy and safety of flemoclav solutab (amoxicillin/clavulanic acid) and wilprafen (josamycin) in treating nonspecif ic vaginitis and cervicitis in real clinical practice. Subject and methods. A multicenter, non-interventional, prospective observational study was conducted in 15 centers from six cities of Russia in 2013 to 2014. The clinical efficiency of therapy was evaluated on the basis of clinical findings (the complete or partial disappearance of clinical signs and symptoms) and investigating physicians’ opinion. Microbiological efficacy was estimated in view of the trend in the eradication of an etiological agent. Results. The study enrolled 711 women (mean age 31.3±7.0years). According to the underlying nosological entity and indications for the use of the drugs, 67.9% of the patients with nonspecific vaginitis received mainly flemoclav solutab; 69% of the patients with cervicitis took wlprafen; 51.5% of the patients with nonspecific vaginitis and cervicitis had a combination of flemoclav solutab and wilprafen. Clinical recovery was observed in the majority of the patients irrespective of their diagnosis: in 212 (98.6%) cases of nonspecific vaginitis, in 220(90.9%) cases of nonspecific cervicitis. No clinical effect of the therapy under study was seen in 3 cases of cervicitis and in 7 cases of nonspecif ic vaginitis and cervicitis. Eradication of etiological agents was recorded in most cases: in 203 (94.4%)patients with nonspecific vaginitis, in 216 (89.3%)patients with cervicitis. The study recorded 14 (1.97%) adverse events, including 5 (0.7%) serious cases. Conclusion. Based on the findings, flemoclav solutab (amoxicillin/clavulanic acid) and wilprafen (josamycin) have confirmed the high efficacy and safety in the treatment of nonspecific vaginitis and/or cervicitis in real clinical practice.

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About the authors

Inna A. Apolikhina

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University

Email: i_apolikhina@oparina4.ru
MD, head of the gynecological department of rehabilitation treatment; Professor of the Department of Obstetrics, Gynecology, Perinatology, and Reproductology

Elena A. Gorbunova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: el_gorbunova@oparina4.ru
doctor of gynecological department of rehabilitation treatment and day hospital

Elena G. Dodova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_dodova@oparina4.ru
a graduate student

Gyulnar F. Gasanova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_gasanova@oparina4.ru
a graduate student

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