ROLE OF GENE IMPRINTING IN INTRAUTERINE GROWTH RESTRICTION


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Abstract

Objective. To analyze the data available in the literature on the impact of epigenetic changes in particular genome imprinting that is of great importance in the development and function of the placenta and in the regulation of fetal growth and development. Subject and methods. The data published in the past 30 years on the impact of epigenetic changes on the regulation of fetal growth were sought in NSBI Pub Med. Results. The paper describes the imprinting mechanisms of genes, the distinctive feature of which is their expression only of one allele; it may be both paternally and maternally inherited. Conclusion. The mechanism of expression can supposedly control the stream of nutrients from mother to fetus, both increasing and decreasing it. This dysregulation may give rise to fetal malformations. Animal testing of reproductive technologies have shown that the changes in the epigenome of an embryo at its early development stage result in imprinting, which may both provoke and constrain intrauterine growth restriction.

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About the authors

Elena I. Degtyareva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_degtyareva@oparina4.ru
PhD, Researcher of the 1st obstetric department of pathology of pregnancy Moscow 117997, Ac. Oparina str. 4, Russia

Olga R. Grigoryan

Endocrinology Research Center, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University

Email: iceberg1995@mail.ru
MD, Chief Scientist at the Department of Endocrine Gynecology with Group of screening and prevention of reproductive disorders Moscow 117036, Dmitry Ulyanov str. 11, Russia; Moscow 119991, Bolshaya Pirogovskaya str. 2, bld. 4, Russia

Natalia N. Volevodz

Endocrinology Research Center, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University

MD, professor, deputy director of the Institute of Pediatric Endocrinology Moscow 117036, Dmitry Ulyanov str. 11, Russia; Moscow 119991, Bolshaya Pirogovskaya str. 2, bld. 4, Russia

Elena N. Andreeva

Endocrinology Research Center, Ministry of Health of Russia

MD, Professor, Head of the Department of Endocrine Gynecology with Group of screening and prevention of reproductive disorders Moscow 117036, Dmitry Ulyanov str. 11, Russia

Natalia I. Klimenchenko

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_klimenchenko@oparina4.ru
PhD, head of the 1st department of pathology of pregnancy Moscow 117997, Ac. Oparina str. 4, Russia

Galina A. Melnichenko

Endocrinology Research Center, Ministry of Health of Russia

MD, professor, corresponding member of the Russian Academy of Sciences, director of the Institute of Clinical Endocrinology Moscow 117036, Dmitry Ulyanov str. 11, Russia

Ivan I. Dedov

Endocrinology Research Center, Ministry of Health of Russia

Ph.D., professor, academician of the Russian Academy of Sciences, Vice-President of RAS, Director of the Endocrinology Moscow 117036, Dmitry Ulyanov str. 11, Russia

Gennady Tihonovich Sukhikh

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

MD, professor, academician of the Russian Academy of Sciences, Director Moscow 117997, Ac. Oparina str. 4, Russia

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