PROSPECTS FOR STUDYING CUMULUS CELL MARKERS TO ASSESS THE QUALITY OF OOCYTES AND EMBRYOS IN ASSISTED REPRODUCTIVE TECHNOLOGY PROGRAMS


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Abstract

Objective. To make a systematic analysis of the data available in the modern literature on the role of cumulus cells in the physiology of the female reproductive system, on the impact of cumulus cell gene expression on embryological characteristics and results of in vitro fertilization (IVF) programs in order to identify biomarkers for the assessment of the quality of oocytes and developing embryos in the assisted reproductive technology technologies programs. Subject and methods. The review includes the past decade data of foreign and Russian articles found in Pubmed on this topic. Results. Recent studies prove that the expression of potentially significant genes in the cumulus cells correlates with the indicators of oocyte quality, the development of embryos, the rate of conception, and the birth of live children. The paper gives the data of the study of the cumulus cell genes that the latter correlate to the possible identification with chromosomal abnormalities by preimplantation genetic diagnosis. Conclusion. The results of the performed investigations confirm the prospects for studying the profile of cumulus cell gene expression, which will be able to more precisely choose embryos to be transferred and, in doing so, to enhance the effectiveness of IVF programs as a whole. Assessment of cumulus cell transcriptome may become a new alternative noninvasive method for diagnosing fetal chromosomal abnormalities.

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About the authors

Natalia Aleksandrovna Safronova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_safronova90@bk.ru
M.D., postgraduate of the department of assisted reproductive technology in infertility treatment Moscow 117997, Ac. Oparina str. 4, Russia

Elena Anatolievna Kalinina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
M.D, Ph.D, The Head of the department of assisted reproductive technology in infertility treatment Moscow 117997, Ac. Oparina str. 4, Russia

Andrew Evgenievich Donnikov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru
PhD, Senior Researcher of molecular-genetical laboratory Moscow 117997, Ac. Oparina str. 4, Russia

Olga Vladimirovna Bourmenskaya

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: o_bourmenskaya@oparina4.ru
Ph.D., Senior Researcher of molecular-genetical laboratory Moscow 117997, Ac. Oparina str. 4, Russia

Natalia Petrovna Makarova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: np.makarova@gmail.com
PhD, Researcher of the department of assisted reproductive technology in infertility treatment Moscow 117997, Ac. Oparina str. 4, Russia

Elena Vladimirovna Kulakova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kulakova@oparina4.ru
PhD, Researcher of the department of assisted reproductive technology in infertility treatment Moscow 117997, Ac. Oparina str. 4, Russia

Kamila Ullubievna Alieva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: k_alieva@oparina4.ru
PhD, Researcher of the department of assisted reproductive technology in infertility treatment Moscow 117997, Ac. Oparina str. 4, Russia

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