ROLE OF WEIGHT LOSS IN THE TREATMENT OF REPRODUCTIVE DISORDERS IN WOMEN


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Abstract

Objective. To analyze current scientific data on the impact of adipose tissue on female reproductive function in obesity. Subject and methods. Scientific sources dealing with the pathogenesis of metabolic disorders associated with obesity and the role of overweight in the development of menstrual and reproductive dysfunctions were reviewed. Results. The current scientific sources describe the theoretical and clinical aspects confirming the relationship between adipose tissue metabolism and hormonal disorders. Anti-obesity medication is shown to be needed in women at the pregnancy preparation stage. Conclusion. Prior to therapy directly aimed at achieving pregnancy, it is absolutely necessary to correct weight and metabolic parameters. The co-use of sibutramine and metformin to treat obesity and to reduce insulin resistance can enhance the efficiency of therapy aimed at recovering reproductive function.

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About the authors

Irina V. Kuznetsova

Research Department of Women's Health, I.M. Sechenov First Moscow State Medical University; Peoples Friendship University of Russia

MD, professor, senior researcher Moscow 119991, Bolshaya Pirogovskaya str. 2, bld. 4, Russia

Yulia B. Uspenskaya

Research Department of Women's Health, I.M. Sechenov First Moscow State Medical University

PhD, a leading researcher Moscow 119991, Bolshaya Pirogovskaya str. 2, bld. 4, Russia

Elina R. Vedzizheva

Research Department of Women's Health, I.M. Sechenov First Moscow State Medical University

a graduate student Moscow 119991, Bolshaya Pirogovskaya str. 2, bld. 4, Russia

Irina V. Vasilyeva

Research Department of Women's Health, I.M. Sechenov First Moscow State Medical University

PhD, a leading researcher Moscow 119991, Bolshaya Pirogovskaya str. 2, bld. 4, Russia

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