IMPAIRED IMMUNE MECHANISMS DUE TO PERINATAL STRESS: EXPERIMENTAL AND CLINICAL FINDINGS


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Abstract

The stress reaction becomes a nonspecific cause of many pathological conditions in which the impaired immune protection mechanisms are of fundamental importance. Objective. To analyze the data available in the literature on studies of immune disorders due to the prenatal stress experienced.ц Subject and methods. The key words, such stress, glucocorticoids, immunity, adrenals, were used to search for data in international and Russian databases. A total of 39 sources on suitable themes were selected. Results. The mechanisms of adaptive responses are interlinked in a complex manner and may be multidirectional with the possibility of changing from protective to destructive ones. They become a basis for the development of pathological processes that depend on the number, intensity, and duration of stress factors and on the specific features of the body and its predisposition to different pathological processes. Conclusion. Impaired immune protection mechanisms are of prime importance in the development of these complications.

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About the authors

Anna Drastamatovna Khudaverdyan

Yerevan State Medical University

Email: anna.khudaverdyan2@mail.ru
MD, PhD, senior lecturer, Department of Obstetrics and Gynecology #2 Armenia, Yerevan 0025, Koryun str. 2

Adelina Levanovna Torgomyan

Yerevan State Medical University

MD, PhD, senior lecturer, Department of Physiology Armenia, Yerevan 0025, Koryun str. 2

Drastamat Nagapetovich Khudaverdyan

Yerevan State Medical University

MD, PhD, professor Head of Physiology department Armenia, Yerevan 0025, Koryun str. 2

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