RESULTS OF MEDICAL THERAPY IN PATIENTS WITH CERVICAL INTRAEPITHELIAL NEOPLASIA I-II (CIN I-II)


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Abstract

Objective. To evaluate the efficiency of medical treatment incorporating promisan in patients with histologically verified cervical intraepithelial neoplasia (CIN) I-II. Subjects and methods. The investigation enrolled 90 reproductive-aged patients who were randomized into three groups. A study group (Group 1) took 2 promisan capsules twice daily during cycle therapy with eubiotics; Group 2 patients underwent radiowave surgery; Group 3 was followed up (a control group). The therapy lasted 12 months. Results. The findings of the clinical trial support the efficiency of promisan therapy. The therapeutic efficiency is proven by the results of cytological monitoring, colposcopy, and polymerase chain reaction. The trial shows that the efficiency of this treatment option can be most adequately evaluated following 12-month therapy. Conclusion. The current treatment policy for CIN I-II in reproductive-aged patients at Stage 1 should be directed at medical treatment incorporating promisan as an effective multitarget agent and at normalization of vaginal biocenosis.

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About the authors

Lev A. Ashrafyan

Russian X-ray Radiology Research Center, Ministry of Health of Russia

Email: levaa2004@yahoo.com
Corresponding Member of the Russian Academy of Sciences, Professor, MD, director of early carcinogenesis, prevention, diagnosis and combined treatment of cancer of the female reproductive organs Moscow 117997, Profsoyuznaya str. 86, Russia

Vsevolod I. Kiselev

Institute of Biomedical Problems, People's Friendship University of Russia

Email: vkis10@mail.ru
Corresponding Member of the Russian Academy of Sciences, Professor, PhD, Deputy Director of Institute of Biomedical Problems Moscow 115093, Podolsk sh. 8/5, Russia

Olga Ivanovna Aleshikova

Russian X-ray Radiology Research Center, Ministry of Health of Russia

Email: olga.aleshikova@gmail.com
PhD, Senior Scientist Laboratory early carcinogenesis, prevention, diagnosis and combined treatment of cancer of the female reproductive organs Moscow 117997, Profsoyuznaya str. 86, Russia

Yulia Vladimirovna Ponomareva

Medical Center, Central Bank of the Russian Federation

Email: juliyapon@mail.ru
MD, head of the gynecological department Moscow 117593, Sevastopol Ave. 66, Russia

Igor Nikolaevich Kuznetsov

IlmixGroup

PhD, General Director Moscow 121248, Kutuzov Ave, Russia

Sophiko Levanovna Vashakmadze

Russian X-ray Radiology Research Center, Ministry of Health of Russia

Email: v.sofia.l@gmail.com
graduate student of the department of early carcinogenesis, prevention, diagnosis and combined treatment of cancer of the female reproductive organs Moscow 117997, Profsoyuznaya str. 86, Russia

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