EFFICIENCY OF ALTERNATIVE THERAPY FOR MENOPAUSAL SYNDROME

Objective. To investigate the efficiency of alternative therapy with genistein synthesized in an active form for menopausal syndrome (MS). Subject and methods. A prospective cohort study was conducted. Examined groups comprised women aged 45 to 60 years: a study group included 30 women with mild and moderate MS; a control group consisted of women without this condition. Basic and special studies were performed; the severity of MS was evaluated by the modified Kupperman-Uvarova menopausal index (MMI) and quality of life in the women of the examined groups was assessed using the international unified SF-36 Health Status Surgery questionnaire. The study group was treated with an active form of genistein (menoryl) in a dose of 30 mg twice daily for 3 months. Then all the aboveenumerated parameters were reestimated in the women of the examined group and compared with the baseline level in the study group and the indicators in the control group. Results. The women with mild and moderate MS showed a reduction in both the physical and psychic heath components of quality of life. The total MMI proved significantly higher in the study group women. Their detailed examination revealed the highest rate of neuroautonomic symptoms among the women with MS. During therapy with active genistein (menoryl), there was a decrease in MMI: from the signs of moderate MS to those of mild MS in the use of phytoestrogens. Menoryl therapy was noted to lead to better quality-of-life indicators in both physical and (predominantly) psychic component.

genistein, quality of life, menopausal syndrome, menoryl