Association of pregnancy outcomes with fetal amino acid metabolism and maternal obesity
- Authors: Bashmakova N.V.1, Tsyvyan P.B.2,1,3, Pestryaeva L.A.1
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Affiliations:
- Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia
- Ural State Medical University
- Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences
- Issue: No 6 (2016)
- Pages: 46-53
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247643
- DOI: https://doi.org/10.18565/aig.2016.6.46-51
- ID: 247643
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Abstract
Objective. To compare the blood concentrations of essential amino acids in mothers and newborn infants during normal pregnancy (a control group; n = 28) and in two study groups of obese women who had given birth to normal (Group 1; n = 46) and low (Group 2; n = 44) birth weight babies. Material and methods. The concentrations of amino acids were measured using an automatic amino acid T339M analyzer (Czechia); biochemical examinations were made on a Sapphire-400 analyzer (Japan). Results. The mean weight of babies in Group 2 was significantly lower than that of those in the control group and Control 1. Cholesterol and lipoproteins were considerably elevated in the obese women, particularly in Group 2. The concentrations of the majority of amino acids and the fetal-maternal concentration gradients were lower in obese women, especially in Group 2. Conclusion. There was a substantial reduction in the amino acid transport-and-concentration function of the placenta in obese women, particularly in those who had given birth to low-birth weight infants, which agrees with the fetal programmed theory of diseases.
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About the authors
Nadezhda V. Bashmakova
Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia
Email: dr@niiomm.ru
MD, professor, Honored Doctor of Russian Federation, Director
Pavel B. Tsyvyan
Ural State Medical University; Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia; Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences
Email: pavel.tsyvian@gmail.com
MD, professor, Head of Department of Normal Physiology, of Ural State Medical University; leading researcher at Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia; senior researcher at Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences.
Lyudmila A. Pestryaeva
Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia
Email: pestryeval@yandex.ru
PhD, Head of Biochemical laboratory
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