ROLE OF OXIDATIVE STRESS AND ANTIOXIDANT DEFENSE IN HUMAN REPRODUCTION


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Abstract

Objective. To carry out a systematic analysis of the data available in the literature on the impact of oxidative stress on fertility of both sexes. Subject and methods. For analysis, foreign and Russian articles published in the past 15 years were sought in the international citation system Pubmed. Results. The current theories of the mechanism of oxidative stress are described; factors that have a key influence on its genesis are discussed. Emphasis is placed on the regulation of the body’s redox biochemical processes in the preparation period before pregnancy. The results of clinical trials showing the efficiency of preventive oxidative stress via recovery of antioxidant factors are analyzed.

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About the authors

Irina Vsevolodovna Kuznetsova

M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: ms.smith.ivk@gmail.com
Doctor of Medicine, Professor, Chief Researcher of Research Center SRA of female health Moscow 119991, Trubetskaya str. 8-2, Russia

References

  1. Gomez-Mejiba S.E., Zhai Z., Акгат Н., Deterding L.J., Hensley К., Smith N. et al. Immuno-spin trapping of protein and DNA radicals: “tagging” free radicals to locate and understand the redox process. Free Radic. Biol. Med. 2009; 46(7): 853-65.
  2. Winterbourn C.C. Reconciling the chemistry and biology of reactive oxygen species. Nat. Chem. Biol. 2008; 4: 278-86.
  3. Dumollard R., Campbell K, Halet G., Carroll J., Swann K. Regulation of cytosolic and mitochondrial ATP levels in mouse eggs and zygotes. Dev. Biol. 2008; 316: 431-40.
  4. Takasaki A., Tamura H, Miwa I., Taketani T, Shimamura K., Sugino N. Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium. Fertil. Steril. 2010; 93: 1851-8.
  5. Pagano G., Talamanca A.A., Castello G., Cordero M.D., d’Ischia M., Gadaleta M.N. et al. Oxidative stress and mitochondrial dysfunction across broad-ranging pathologies: toward mitochondria-targeted clinical strategies. Oxid. Med. Cell Longev. 2014; 2014: 541230.
  6. Fischer R., Maier O. Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF. Oxid. Med. Cell. Longev. 2015; 2015: 610813.
  7. Hussein H, Saheb S., Couturier M., Atassi M., Orsoni A., Carrie A., Therond P. et al. Small, dense high-density lipoprotein 3 particles exhibit defective antioxidative and anti-inflammatory function in familial hypercholesterolemia: Partial correction by low-density lipoprotein apheresis. J. Clin. Lipidol. 2016; 10(1): 124-33.
  8. Deferme L., Briede J.J., Gaessen S.M., Cavill R.r Kleinjans J.C. Cell line-specific oxidative stress in cellular toxicity: A toxicogenomics-based comparison between liver and colon cell models. Toxicol. In Vitro. 2015; 29(5): 845-55.
  9. Palini S., Benedetti S., Tagliamonte M.C., De Stefani S., Primiterra M., Polli V et al. Influence of ovarian stimulation for IVF/ICSI on the antioxidant defence system and relationship to outcome. Reprod. Biomed. Online. 2014; 29(1): 65-71.
  10. Najafi T, Novin M.G., Ghazi R-, Khorram O. Altered endometrial expression of endothelial nitric oxide synthase (eNOS) in women with unexplained recurrent miscarriage and infertility. Reprod. Biomed. Online. 2012; 25(4): 408-14.
  11. RichardP.U., DuskeyJ.T., StolarovS., SpulberM., Palivan C.G. New concepts to fight oxidative stress: nanosized three-dimensional supramolecular antioxidant assemblies. Expert Opin. Drug Deliv. 2015; 12(9): 1527-45.
  12. Goud A.P., Goud P.T., Diamond M.P., Gonik B., Abu-Soud H.M. Reactive oxygen species and oocyte aging: role of superoxide, hydrogen peroxide, and hypochlorous acid. Free Radic. Biol. Med. 2008; 44: 1295-304.
  13. Lebovitz O., Orvieto R. Treating patients with “thin” endometrium - an ongoing challenge. Gynecol. Endocrinol. 2014; 30(6): 409-14.
  14. Firns S., Cruzat V.F., Keane K.N., Joesbury K.A., Lee A.H., Newsholme P, Yovich J.L. The effect of cigarette smoking, alcohol consumption and fruit and vegetable consumption on IVF outcomes: a review and presentation of original data. Reprod. Biol. Endocrinol. 2015;13: 134.
  15. Agarwal A., Aponte-Mellado A., Premkumar B.J., Shaman A., Gupta S. The effects of oxidative stress on female reproduction: a review. Reprod. Biol. Endocrinol. 2012; 10: 49.
  16. Oliveras-Ldpez M.J., Ruiz-Prieto I., Bolahos-Rios P, De la Cerda E, Martin F, Jauregui-Lobera I. Antioxidant activity and nutritional status in anorexia nervosa: effects of weight recovery. Nutrients. 2015; 7(4): 2193-208.
  17. Robbins C.L., Zapata L.B., Farr S.L., Kroelinger C.D., Morrow B., Ahluwalia I. et al.; Centers for Disease Control and Prevention (CDC). Core state preconception health indicators - pregnancy risk assessment monitoring system and behavioral risk factor surveillance system, 2009. MMWR Surveill. Summ. 2014; 63(3): 1-62.
  18. Хорошилов И.Ғ., Успенский Ю.В. Новые подходы в лечебном питании беременных и кормящих женщин. Гинекология. 2008; 4: 67-77.
  19. Fares S., Sethom М.М., Khouaja-Mokrani С., Jabnoun S. et al. Vitamin a, e, and d deficiencies in tunisian very low birth weight neonates: prevalence and risk factors. Pediatr. Neonatol. 2014; 55(3): 196-201.
  20. Gareskog M. Combined supplementation of folic acid and vitamin E diminishes diabetes-induced embryotoxicity in rats. Birth Defects Res. Clin. Mol. Teratol. 2006; 76(6): 483-90.
  21. Catov J.M., Bodnar L.M., Olsen J., Olsen S., Nohr E.A. Periconceptional multivitamin use and risk of preterm or small-for-gestational-age births in the Danish National Birth Cohort. Am. J. Clin. Nutr. 2011; 94(3): 906-12.
  22. Baumgartner M.R. Vitamin-responsive disorders: cobalamin, folate, biotin, vitamins B1 and E. Handb. Clin. Neurol. 2013; 113: 1799-810.
  23. Mozdarani H. Numerical chromosome abnormalities in 8-cell embryos generated from gamma-irradiated male mice in the absence and presence of vitamin E. Int. J. Radiat. Biol. 2006; 82(11): 817-22.
  24. Gurgen S.G., Erdogan D., Bmas C., Kaplan oglu G. T, Ozer C. Chemoprotective effect of ascorbic acid, a-tocopherol, and selenium on cyclophosphamide- induced toxicity in the rat ovarium. Nutrition. 2013; 29(5): 777-84.
  25. Zal F, Mostafavi-Pour Z., Amini E, Heidari A. Effect of vitamin E and C supplements on lipid peroxidation and GSH-dependent antioxidant enzyme status in the blood of women consuming oral contraceptives. Contraception. 2012; 86(1): 62-6.
  26. Klemmensen A., Tabor A., Osterdal M.L. Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57346 women. BJOG. 2009; 116(7): 964-74.
  27. Xing X., Tao E Advance of study on vitamin A deficiency and excess associated with congenital heart disease. Wei Sheng Yan Jiu. 2008; 37(6): 754-6.
  28. Mark M., Ghyselinck N.B., Chambon P. Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissection of the retinoic acid signaling pathway during mouse embryogenesis. Annu. Rev. Pharmacol. Toxicol. 2006; 46: 451-80.
  29. Mark M., Ghyselinck N.B., Chambon P Function of retinoic acid receptors during embryonic development. Part 1. Nucl. Recept. Signal. 2009; 7: 2-5.
  30. Sorg O., Saurat J.H. Topical retinoids in skin ageing: a focused update with reference to sun-induced epidermal vitamin A deficiency. Dermatology. 2014; 228(4): 314-25.
  31. Ushida Y., Matsui T, Tanaka M., Matsumoto K, Hosoyama H et al. Endothelium-dependent vasorelaxation effect of rutin-free tartary buckwheat extract in isolated rat thoracic aorta. J. Nutr. Biochem. 2008; 10: 700-7.
  32. Gonzalez-Manzano S., Gonzalez-Paramas A.M., Delgado L., Patianna S., Surco-Laos Ғ. et al. Oxidative status of stressed Caenorhabditis elegans treated with epicatechin. J. Agric. Food Chem. 2012; 60: 8911-6.
  33. Kampkotter A., Nkwonkam C.G., Zurawski R.F., Timpel C., Chovolou Y. et al. Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans. Toxicology. 2007; 234: 113-23.
  34. Kampkotter A., Pielarski T, Rohrig R., Timpel C., Chovolou Y et al. The Ginkgo biloba extract EGb761 reduces stress sensitivity, ROS accumulation and expression of catalase and glutathione S-transferase 4 in Caenorhabditis elegans. Pharmacol. Res. 2007; 55: 139-47.
  35. Akondi B.R., Challa S.R., Akula A. Protective effects of rutin and naringin in testicular ischemia-reperfusion induced oxidative stress in rats. J. Reprod. Infertil. 2011; 12(3): 209-14.
  36. Quinzii CM., Hirano M. Coenzyme Q and mitochondrial disease. Dev. Disabil. Res. Rev. 2010; 16(2): 183-8.
  37. Bentov Y., Hannam T, Jurisicova A., Esfandiari N., Casper R.F. Coenzyme Q10 supplementation and oocyte aneuploidy in women undergoing IVF-ICSI treatment. Clin. Med. Insights Reprod. Health. 2014; 8: 31-6.
  38. Talevi R., Barbato V., Fiorentino I., Braun S., Longobardi S., Gualtieri R. Protective effects of in vitro treatment with zinc, d-aspartate and coenzyme qlO on human sperm motility, lipid peroxidation and DNA fragmentation. Reprod. Biol. Endocrinol. 2013; 11: 81.
  39. Gvozdjdkovd A., Kucharskd J., Dubravicky J., Mojto V., Singh R.B. Coenzyme QlO, a-tocopherol, and oxidative stress could Be important metabolic biomarkers of male infertility. Dis Markers. 2015; 2015: 827941.
  40. Durairajanayagam D., Agarwal A., Ong C., Prashast P. Lycopene and male infertility. Asian J. Androl. 2014; 16(3): 420-5.
  41. Sharma R., Biedenharn K.R., Fedor J.M., Agarwal A. Lifestyle factors and reproductive health: taking control of your fertility. Reprod. Biol. Endocrinol. 2013; 11: 66.

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