RISK FACTORS FOR PLACENTA PREVIA


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Abstract

Objective. To identify risk factors for original placenta previa, its preservation by the time of delivery, and poor outcomes for mother and fetus. Subjects and methods. Clinical and paraclinical characteristics were comparatively analyzed in 70 patients with placenta previa by the time of labor, in 150 parturients with a positive migration in second-trimester placenta previa, and in 100parturients with physiological placentation. In addition to compulsory examinations provided by guidance documents, all the patients in the comparison groups underwent molecular genetic testing of the alleles of the hemostatic genes, the participants of hemostatic reactions, and the folate metabolic genes by a PCR assay. Parametric and nonparametric statistical methods were used for the statistical processing of the findings. Results. The history of hormone-dependent gynecological diseases (p < 0.001), infertility (p < 0.001), intrauterine contraceptive devices (p < 0.05), and hypertensive syndrome (p < 0.001), as well as the associations between defective alleles of the genes of hemostasis and folate metabolism (p < 0.01), hepatitis B and C viruses (p < 0.001), and autoimmune processes (p < 0.001) are risk factors for fully preserving the placental previa for delivery.

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About the authors

Natalya I. Fadeeva

Altai State Medical University

Email: nat2fad@hotmail.com
MD, Professor, head of the Department of obstetrics and gynecology Barnaul 656038, Lenina pr. 40, Russia

Olga A. Belnitskaya

Altai State Medical University

Email: belnickaya@yandex.ru
candidate of medical sciences, associate professor in the Department of obstetrics and gynecology Barnaul 656038, Lenina pr. 40, Russia

Irina A. Myadelets

Diagnostic Center of the Altai region

Email: Myad-irina@yandex.ru
candidate of medical Sciences, obstetrician-gynecologist of the Department of prenatal diagnosis Barnaul 656038, pr. Komsomolskiy 75a, Russia

Galina V. Serdyuk

Altai Branch of Hematology Research Center, Ministry of Health of Russia

Email: Gvser@mail.ru
MD, senior researcher of laboratory of Hematology Barnaul 656045, Lyapidevskogo str. 1, bldg. 2, Russia

Mariya G. Nikolaeva

Altai State Medical University

Email: nikolmg@yandex.ru
candidate of medical sciences, associate professor in the Department of obstetrics and gynecology Barnaul 656038, Lenina pr. 40, Russia

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