Principles of pregnancy management in women with Ph-negative myeloproliferative neoplasms

Objective. To comparatively analyze the course of 167 pregnancies in 95 women with Ph-negative myeloproliferative neoplasms (MPN) who have been treated and untreated for the underlying disease. Material and methods. Complications of pregnancy, delivery, and postpartum period and neonatal health status were evaluated in both groups. Results. The creation of a program for pregnancy preparation and management in women with Ph-negative MPN led to a significant reduction in reproductive losses from 76.3% to 3.3% and to a downward trend in the number of pregnancy complications from 84,6% to 74.2%. The health status and frequency of malformations in children born to the mothers with MPN who had been treated during pregnancy did not differ from those in the healthy population. Conclusion. Pregnant women with Ph-negative MPN belong to a high-risk group. The results of the investigation have shown that pregnancy has no impact on the course of myeloproliferative disease. The algorithm elaborated by the authors could substantially reduce reproductive losses and the number of pregnancy complications in women with MPN. The health status of the children does not differ from that in the general population.

Ph-negative myeloproliferative neoplasms, pregnancy, polycythemia vera, essential thrombocythemia, primary myelofibrosis, recombinant interferon-alpha