Clinical and immunological characteristics of newborn infants from mothers with cancers

M. I Makieva; Макиева Мзия Ильинична; N. K Matveeva; Матвеева Наталия Константиновна; L. V Vanko; Ванько Людмила Викторовна; T. A Tsoi; Цой Татьяна Александровна; A. S Zhukova; Жукова Анастасия Сергеевна; E. A Shatalova; Шаталова Екатерина Александровна; E. S Polushkina; Полушкина Евгения Сергеевна; M. V Averyanova; Аверьянова Марина Владимировна; L. A Timofeeva; Тимофеева Лейла Акакиевна; L. V Krechetova; Кречетова Любовь Валентиновна; V. V Zubkov; Зубков Виктор Васильевич; P. G Shmakov; Шмаков Роман Георгиевич

doi:10.18565/aig.2017.ll.92-99

Clinical and immunological characteristics of newborn infants from mothers with cancers

Authors: Makieva M.I¹, Matveeva N.K¹, Vanko L.V¹, Tsoi T.A¹, Zhukova A.S¹, Shatalova E.A¹, Polushkina E.S¹, Averyanova M.V², Timofeeva L.A¹, Krechetova L.V¹, Zubkov V.V¹, Shmakov P.G¹^,3
Affiliations:
1. National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after V.I. Kulakov
2. Pirogov Russian National Research Medical University
3. Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia
Issue: No 11 (2017)
Pages: 92-99
Section: Articles
URL: https://journals.eco-vector.com/0300-9092/article/view/248083
DOI: https://doi.org/10.18565/aig.2017.ll.92-99
ID: 248083

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Abstract

Objective. To provide the clinical characteristics of the health status and to assess the immune status of neonates born to mothers with cancer who had received chemotherapy during pregnancy. Subjects and methods. Pregnant women with cancer (n = 60) and their newborn infants (n = 64) underwent physical examination. Ultrasonography was used to examine the brain, abdominal organs, kidneys, and heart in ail the babies. Flow cytometry was employed to assess the composition of lymphocyte subpopulations in the umbilical cord blood of 27 newborn infants and in the venous blood of their mothers. Results. The babies born to women with cancer had lower weight and height and higher frequency of complications in the early neonatal period, which can be attributed to a lower gestational age due to premature delivery that necessitated a more aggressive therapy in the mother. The signs that stemmed from imbalance in the cellular component of immunity, which were manifested by decreases in the immunoregulatory index and in the count of B lymphocytes and by increases in the level of activated T lymphocytes and in that of lymphocytes ready for apoptosis, were observed in pregnant women with cancer who had received immunosuppressive therapy. The umbilical cord blood of their newborn infants displayed a reduction in the relative content of B lymphocytes in the absence of significant differences in the number of T lymphocytes in the control group. Conclusion. The satisfactory status of neonates, the course of the neonatal period, and the lack of considerable changes in the immune status of newborn infants from cancer mothers receiving chemotherapy may be indicative of the adequacy of the performed drug therapy necessary to suppress disease activity and to ensure a successful pregnancy.

Keywords

pregnancy, oncology, chemotherapy, newborn infant, immunity