Genital herpes: diagnosis, suppressive therapy relevance, prevention


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Abstract

Objective. To carry out a systematic analysis of the data available in modern literature on genital herpes and to evaluate the efficacy of valvir (valaciclovir) in the treatment of patients with recurrent genital herpes. Material and methods. The article includes the data of foreign and Russian articles published in the past 10 years and found in Pubmed on this topic. Results. Genital herpes is one of the most common sexually transmitted infections, and their associated physical and psychological diseases are frequently underestimated. Conclusion. Valvir (valaciclovir) is a standard treatment for genital herpes in immunocompetent patients. The investigations have shown that the drug is effective in suppressing the virus and preventing recurrent genital herpes.

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About the authors

Elena Vladimirovna Enkova

N.N. Burdenko Voronezh State Medical University

Email: evenkova@vrngmu.ru
MD, professor of the Department of Surgery, Obstetrics and Gynecology, Institute of Cardiovascular Diseases

References

  1. Sauerbrei A., Schmitt S., Scheper T., Brandstädt A., Saschenbrecker S., Motz M. et al. Seroprevalence of herpes simplex virus type 1 and type 2 in Thuringia, Germany, 1999 to 2006. Euro Surveill. 2011; 16(44). pii: 20005.
  2. Wutzler P., Doerr H.W., Färber I., Eichhorn U., Helbig B., Sauerbrei A. et al. Seroprevalence of herpes simplex virus type 1 and type 2 in selected German populations-relevance for the incidence of genital herpes. J. Med. Virol. 2000; 61(2): 201-7.
  3. Langenberg A.G., Corey L., Ashley R.L., Leong W.P., Straus S.E. A prospective study of new infections with herpes simplex virus type 1 and type 2. Chirion HSV Vaccine Study Group. N. Engl. J. Med. 1999; 341(19): 1432-8.
  4. Bernstein D.I., Bellamy A.R., Hook E.W. 3rd., Levin M.J., Wald A., Ewell M.G. et al. Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women. Clin. Infect. Dis. 2013; 56(3): 344-51.
  5. Corey L., Adams H.G., Brown Z.A., Holmes K.K. Genital herpes simplex virus infections: clinical manifestations, course, and complications. Ann. Intern. Med. 1983; 98(6): 958-72.
  6. Stevens J.G., Cook M.L. Latent herpes simplex virus in spinal ganglia of mice. Science. 1971; 173(3999): 843-5.
  7. Verna J.J., Mannix M.L., Rooney J.F., Notkins A.L., Straus S.E. Reactivation of latent herpes simplex virus infection by ultraviolet light: a human model. J. Am. Acad. Dermatol. 1987; 17(3): 473-8.
  8. Rand K.H., Hoon E.F., Massey J.K., Johnson J.H. Daily stress and recurrence of genital herpes. Arch. Intern. Med. 1990; 150(9): 1889-93.
  9. Gupta R., Warren T., Wald A. Genital herpes. Lancet. 2007; 370(9605): 2127-37.
  10. Whitley R.J., Roizman B. Herpes simplex virus infections. Lancet. 2001; 357(9267): 1513-8.
  11. Catotti D.N., Clarke P., Catoe K.E. Herpes revisited. Still a cause of concern. Sex. Transm. Dis. 1993; 20(2): 77-80.
  12. Roberts C.M., Pfister J.R., Spear S.J. Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students. Sex. Transm. Dis. 2003; 30(10): 797-800.
  13. Pena K.C., Adelson M.E., Mordechai E., Blaho J.A. Genital herpes simplex virus type 1 in women: detection in cervicovaginal specimens from gynecological practices in the United States. J. Clin. Microbiol. 2010; 48(1): 150-3.
  14. Sauerbrei A., Wutzler P. Herpes simplex and varicella-zoster virus infections during pregnancy current concepts of prevention, diagnosis and therapy. Part 1: Herpes simplex virus infections. Med. Microbiol. Immunol. 2007; 196(2): 89-94.
  15. Rudnick C.M., Hoekzema G.S. Neonatal herpes simplex virus infections. Am. Fam. Physician. 2002; 65(6): 1138-42.
  16. Deutsche STI-Gesellschaft. S1-Leitlinie STI/STD - Beratung, Diagnostik und Therapie. Available at: http://www.awmf.org/uploads/tx_szleitlinien/059-006l_S1_STI_STD-Beratung_2015-07.pdf last access: 22.06.2016
  17. LeGoff J, Péré H., Bélec L. Diagnosis of genital herpes simplex virus infection in the clinical laboratory. Virol. J. 2014; 11: 83.
  18. Workowski K.A., Bolan G.A.; Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm. Rep. 2015; 64(RR-03): 1-137.
  19. Patel R., Alderson S., Geretti A., Nilsen A., Foley E., Lautenschlager S. et al. European guideline for the management of genital herpes, 2010. Int. J. STD AIDS. 2011; 22(1): 1-10.
  20. Wald A., Huang M.L., Carrell D., Selke S., Corey L. Polymerase chain reaction for detection of herpes simplex virus (HSV) DNA on mucosal surface: comparison with HSV isolation in cell culture. J. Infect. Dis. 2003; 188(9): 1345-51.
  21. Public Health Agency of Canada. Canadian guidelines on sexually transmitted infections. Section 5 - Management and treatment of specific infections. Genital herpes simplex virus (HSV) infections. Available at: http:// www.phac-aspc.gc.ca/std-mts/sti-its/cgsti-ldcits/section-5-4-eng.php last access: 11.08.2016
  22. German STI-Society. STI-Treatment Pocket Guide. Available at: http://dstig. de/images/DSTIG-Flyer/Leitfaden/sti-treatment%2520pocket%2520gui de_2014.2015_web.pdf last access: 22.06.2016
  23. De Clercq E. Selective anti-herpesvirus agents. Antivir. Chem. Chemother. 2013; 23(3): 93-101.
  24. Le Cleach L., Trinquart L., Do G, Maruani A., Lebrun-Vignes B., Ravaud P., Chosidow O. Oral antiviral therapy for prevention of genital herpes outbreaks in immunocompetent and nonpregnant patients (review). Cochrane Database Syst. Rev. 2014; (8): CD009036.
  25. Hollier L.M., Wendel D. Third trimester antiviral prophylaxis for preventing maternal genital herpes simplex virus (HSV) recurrences and neonatal herpes. Cochrane Database Syst. Rev. 2008; (1): CD004946.

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