Combined use of antibiotics and probiotics as a way to enhance the efficiency of treatment for genital infections

Objective. To evaluate the efficiency of combined use of antibiotics and probiotics in patients with bacterial vaginosis and trichomoniasis. Material and methods. Based on subjective and objective (pH and redox potential, the number of lactobacilli, T. vaginalis, A. vaginae, G. vaginalis, Amsel, Nugent and Hay-Ison scoring criteria) parameters, the investigators evaluated the efficiency of combined use of oral metronidazole and the intravaginal probiotic lactoginal. The control group received traditional therapy. Results. The use of probiotics in combination with metronidazole led to a more intense normalization of the physicochemical and microbiological parameters of the biotope. The eff iciency of this therapy regimen was 80%, while that of traditional therapy was 20%. Conclusion. Potentiation of the antimicrobial activity of antibiotics by probiotics has been confirmed in vivo. Probiotics that potentiate the activity of antibiotics are able to replenish the function of the normal microflora during antibiotic therapy. A question is raised as to the need for a new indication for the use of probiotics - to improve the efficiency of antibiotic therapy.

Lactobacillus casei subsp. rhamnosus LCR35, Lactobacillus casei subsp. rhamnosus LCR35, antibiotic therapy, bacterial vaginosis, lactobacilli, metronidazole, probiotics, trichomoniasis