Combined use of antibiotics and probiotics as a way to enhance the efficiency of treatment for genital infections


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Objective. To evaluate the efficiency of combined use of antibiotics and probiotics in patients with bacterial vaginosis and trichomoniasis. Material and methods. Based on subjective and objective (pH and redox potential, the number of lactobacilli, T. vaginalis, A. vaginae, G. vaginalis, Amsel, Nugent and Hay-Ison scoring criteria) parameters, the investigators evaluated the efficiency of combined use of oral metronidazole and the intravaginal probiotic lactoginal. The control group received traditional therapy. Results. The use of probiotics in combination with metronidazole led to a more intense normalization of the physicochemical and microbiological parameters of the biotope. The eff iciency of this therapy regimen was 80%, while that of traditional therapy was 20%. Conclusion. Potentiation of the antimicrobial activity of antibiotics by probiotics has been confirmed in vivo. Probiotics that potentiate the activity of antibiotics are able to replenish the function of the normal microflora during antibiotic therapy. A question is raised as to the need for a new indication for the use of probiotics - to improve the efficiency of antibiotic therapy.

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作者简介

Andrey Sgibnev

Institute of Cellular and Intracellular Symbiosis, Ural Branch, Russian Academy of Sciences

Email: sgibnew72@yandex.ru
doctor of Biology, associate professor, leading researcher, Laboratory for the study of the mechanisms of formation microbiocenoses of humans

Elena Kremleva

Institute of Cellular and Intracellular Symbiosis, Ural Branch, Russian Academy of Sciences; Orenburg State Medical University

Email: 1@mail.ru
MD, leading researcher, Laboratory for the study of the mechanisms of formation microbiocenoses of humans; Associate Professor, Department of Obstetrics and Gynecology

Yuliya Shchetinina

Orenburg State Medical University

Email: koto-yuliya@yandex.ru
PhD, Associate Professor, Department of Obstetrics and Gynecology

Yuliya Cherkasova

Institute of Cellular and Intracellular Symbiosis, Ural Branch, Russian Academy of Sciences

Email: yulya.cherkasova.2018@mail.ru
postgraduate

参考

  1. UN General Assembly Resolution A/RES/71/3, 5 October 2016, A/ RES/71/3 (2016) - Political Declaration of the high-level meeting of the General Assembly on antimicrobial resistance. Available at: https:// docum ents-dds-ny.un.org/doc/UND0C/GEN/N16/310/65/PDF/ N1631065.pdf?0penElement.
  2. Mishra R.K., Segal E., Lipovsky A., Natan M., Banin E., Gedanken A. New life for an old antibiotic. ACS Appl. Mater. Interfaces. 2015; 7(13): 7324-33.
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  4. Сгибнев А.В., Кремлева Е.А. Потенцирование активности антибиотиков метаболитами нормальной вагинальной микрофлоры. Акушерство и гинекология. 2017; 3: 108-14.
  5. Sgibnev A., Kremleva E. Influence of hydrogen peroxide, lactic acid, and surfactants from vaginal lactobacilli on the antibiotic sensitivity of opportunistic bacteria. Probiotics Antimicrob. Proteins. 2017; 9(2): 131-41.
  6. Brotman R.M., Bradford L.L., Conrad M., Gajer P., Ault K., Peralta L. et al. Association between Trichomonas vaginalis and vaginal bacterial community composition among reproductive-age women. Sex. Transm. Dis. 2012; 39(10): 807-12.
  7. Torok M.R., Miller W.C., Hobbs M.M., MacdonaldP.D., Leone P.A., Schwebke J.R. et al. The association between Trichomonas vaginalis infection and level of vaginal lactobacilli, in nonpregnant women. J. Infect. Dis. 2007; 196(7):1102-7.
  8. WHO. Global incidence and prevalence of selected sexually transmitted infections -2008. Geneva: World Health Organization; 2012: 1-20.
  9. Bouchemal K., Bories C., Loiseau P.M. Strategies for prevention and treatment of Trichomonas vaginalis infections. Clin. Microbiol. Rev. 2017; 30(3): 811-25.
  10. Whitman W.B., Goodfellow M., Kampfer P., Busse H.-J., Trujillo M.E., Ludwig W, eds. Bergey’s manual of systematic bacteriology. 2nd ed. vol. 5(Pt A and B). New York: Springer-Verlag; 2012.

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