Diagnosis and treatment of recurrent vaginal discharge of non-Candida origin in women

Objective. To carry out a systems analysis of the data available in the current literature on the diagnosis and therapy of recurrent vaginal discharge of non-candidiasis origin. Material and methods. The review includes the data of foreign and Russian articles published in the past 10 years and found in Pubmed on this topic. The guidelines of the US Center for Disease Control and Prevention (CDC), the European International Union Against Sexually Transmitted Infections (IUSTI), and the Russian Society of Dermatovenereologists and Cosmetologists (RSDC) were analyzed. Results. The paper describes standard and alternative therapy regimens and notes the importance of therapy tolerability as one of the components of adherence to treatment. Conclusion. The standard therapy for uncomplicated trichomoniasis or bacterial vaginosis yields a good effect in most cases. However, the international guidelines contain no clear indication for the algorithm of a physician’s actions in the recurrent course of these diseases. 5-nitroimidazole remains the drug of choice for the treatment of trichomoniasis and this drug and clindamycin for bacterial vaginosis. Due to its better tolerability and lower frequency of adverse reactions, Ornidazole is recommended by the RSDC as an alternative agent for better compliance with 5-nitroimidazoles.

bacterial vaginosis, trichomoniasis, clinical guidelines, 5-nitroimidazole tolerability, ornidazole