Lactobacteria LCR35 for prevention of relapse of vulvovaginal candidiasis: results of the multicenter open noninterventional study


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Objective. To evaluate the efficacy and safety of the preparation containing the culture of lactobacilli LCR35 (vaginal capsules) in preventing recurrence of vulvovaginal candidiasis after local and/or systemic treatment with antifungal drugs. Subjects and methods. A total of 800 patients diagnosed with acute vulvovaginal candidiasis (VVC) participated in the study. Depending on the therapy the patients were divided into two groups. Patients in group 1 (n = 200) received a course of VVC therapy with local and/or systemic antifungal drugs. Patients of group 2 (n = 600) received a course of VVC therapy with local and/or systemic antifungal drugs, and then a preparation containing a culture of lactobacilli LCR35 (lactogynal) in one capsule vaginally at night for 21 days. The period of dynamic observation of patients after the end of the therapy was five months, during which the recurrence of VVC was recorded. The study also assessed the level of patients’ adherence to the therapy using a multifactorial questionnaire. Statistical data analysis was performed using IBM SPSS 23. Results. The period of time before the relapse of VVC was significantly longer in group 2 than in group 1, it was 98.08 ± 7.66 days and 86.19 ± 3.91 days, respectively, p = 0.037 The incidence of relapses of VVC was significantly lower in group 2(4.7%) compared to group 1 (34.9%), p < 0.001. Evaluation of patients’ adherence to the treatment with the investigational drug lactogynal showed a high level (178.16 ± 1.16 points). The treatment groups analyzed were comparable in the number and severity of adverse events. Conclusion. The presented results demonstrate the efficacy and safety of the preparation containing the culture of lactobacilli LCR35 (lactogynal) in the complex therapy of VVC.

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作者简介

Igor Manukhin

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Email: mgmsugyn@mail.ru
MD, Honored Doctor of Russia, professor, Department of Obstetrics and Gynecology, Medical Faculty

Elena Abashova

D.O. Ott Scientific Research Institute of Obstetrics and Gynecology

Email: abashova@yandex.ru
PhD, senior researcher, Department of Endocrinology Reproduction

Marina Bazina

Krasnoyarsk State Medical University named after prof. V.F. Voyno-Yasenetskii

MD, professor, Department of Obstetrics and Gynecology

Alexey Gerasimov

Ivanovo State Medical Academy

MD

Nadezhda Katkova

Privolzhsky Research Medical University

Email: rector@gma.nnov.ru
MD, associate professor of the Department of Obstetrics and Gynecology, Postgraduate Education Faculty

Larisa Maltseva

Kazan State Medical Academy

Email: laramalc@mail.ru
MD, professor, head of the Department of Obstetrics and Gynecology № 1

Anna Olina

D.O. Ott Scientific Research Institute of Obstetrics and Gynecology

Email: olina29@mail.ru
MD, professor of Department of obstetrics and gynecology

Ludmila Tkachenko

Volgograd State Medical University

Email: tkachenko.fuv@mail.ru
MD, professor, head of Department of Obstetrics and Gynecology, Faculty of advanced training of doctors

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