The role of magnetic resonance imaging in evaluating the effectiveness of neoadjuvant chemotherapy in patients with locally advanced cervical cancer


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Abstract

Aim. To investigate the role of magnetic resonance imaging (MRI) in evaluating the effectiveness of neoadjuvant chemotherapy in patients with locally advanced cervical cancer. Materials and methods. The study comprised 67 patients with locally advanced cervical cancer undergoing neoadjuvant chemotherapy followed by radical hysterectomy in those, who achieved a response. Clinical evaluation included general clinical examination and MRI. Results. The reduction of the tumor volume in patients with different cancer stages ranged from 23.2 to 52.1% according to clinical examination and MRI. Fifty-nine patients (88.1%) underwent surgery after neoadjuvant chemotherapy, including all 17patients with stages IB2/IIA2, and 31 (91.2%) and 11 (68.8%) patients with stage IIB and IIIB cervical cancer, respectively. Conclusion. Neoadjuvant chemotherapy for locally advanced cervical cancer results in the tumor response that allows radical surgery to be undertaken. MRI can be used to obtain objective data on changes in the cervical tumor volume during neoadjuvant chemotherapy.

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About the authors

Dmitry L. Ovodenko

V.I. Kulakov NMRC for OG&P of Minzdrav of Russia

Email: d_ovodenko@oparina4.ru
Ph.D., Clinical Care Supervisor at the Department of Innovative Oncology and Gynecology, Oncologist

Vladimir G. Bychenko

V.I. Kulakov NMRC for OG&P of Minzdrav of Russia

Email: v_bychenko@oparina4.ru
Ph.D., Head of the Department of Radiology, Radiologist

Grigoriy N. Khabas

V.I. Kulakov NMRC for OG&P of Minzdrav of Russia

Email: g_khabas@oparina4.ru
Ph.D., Head of the Department of Innovative Oncology and Gynecology

Dmitry M. Akinfiev

V.I. Kulakov NMRC for OG&P of Minzdrav of Russia

Email: E-maihg_khabas@oparina4.ru
Interventional Radiologist at the Department of Radiology

Anna S. Makarova

V.I. Kulakov NMRC for OG&P of Minzdrav of Russia

Email: a_makarova@oparina4.ru
Obstetrician-Gynecologist at the Department of Innovative Oncology and Gynecology

Julia S. Golitsyna

V.I. Kulakov NMRC for OG&P of Minzdrav of Russia

Email: yu_golitsyna@oparina4.ru
Obstetrician-Gynecologist at the Department of Innovative Oncology and Gynecology

Alexander A. Seregin

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: ggk32@ya.ru
Ph.D. Student

Lev A. Ashrafyan

V.I. Kulakov NMRC for OG&P of Minzdrav of Russia

Email: Levaa2004@yahoo.com
Academician of the RAS, Dr.Med.Sci., Professor, Deputy Director

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