WHY DOES PREECLAMPSIA TRANSFORM INTO HELLP SYNDROME? THE ROLE OF THE COMPLEMENT SYSTEM


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Abstract

Consideration of the clinical manifestations of severe preeclampsia (PE) and HELLP syndrome in the context of thrombotic microangiopathy allows a fresh look at the pathogenesis of these gestational complications. There is new evidence for a similar mechanism for endothelial damage in severe PE, HELLP syndrome, and atypical hemolytic uremic syndrome (aHUS), which is realized due to the excessive activation of the alternative complement pathway. An investigation of the role of complement factors in the pathogenesis, course and progression of PE with realization in the HELLP syndrome will be able to further consider them as markers for predicting severe PE complications.

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About the authors

Alexander N. STRIZHAKOV

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Academician of the Russian Academy of Sciences, Professor, Head of the Department of Obstetrics, Gynecology and Perinatology of the Medical Faculty Moscow, Russia

Elena V. TIMOKHINA

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

D.Sci. (Medicine), Professor of the Department of Obstetrics, Gynecology and Perinatology of the Medical Faculty Moscow, Russia

Irina A. FEDYUNINA

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: irina.fedjunina@mail.ru
assistant of the Department of Obstetrics, Gynecology and Perinatology of the Medical Faculty Moscow, Russia

Irina V. IGNATKO

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

D.Sci. (Medicine), Professor of the Department of Obstetrics, Gynecology and Perinatology of the Medical Faculty Moscow, Russia

Alexander G. ASLANOV

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

assistance of professor of the Department of Obstetrics, Gynecology and Perinatology of the Medical Faculty Moscow, Russia

Irina M. BOGOMAZOVA

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

assistance of professor of the Department of Obstetrics, Gynecology and Perinatology of the Medical Faculty Moscow, Russia

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