First experience of autologous platelet rich plasma injection into the endometrium in patients with uterine factor infertility


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Abstract

Objective. To assess the effectiveness of intraendometrial injecting autologous platelet-rich plasma (PRP) in infertile women with thin endometrium which is refractory to treatment. Materials and methods. The study included 42 patients aged 18-38 years (34.9 (3.6) years) with endometrial thickness 47 mm during the implantation window. All patients were injected 40 (5) ml of autologous PRP into the endometrium during the proliferative phase of the menstrual cycle, preceding the cycle of embryo transfer into the uterine cavity. Results. After autologous PRP injection into the endometrium in the following menstrual cycle, there was a statistically significant increase (p<0.01) in endometrial thickness during the implantation window in patients receiving estrogen-containing hormone therapy. Clinical pregnancy occurred in 33.3% of women (n=14) after embryo transfer. No cases of allergic reaction or infectious complications were revealed after the intervention. Conclusion. The study has demonstrated, for the first time, a new approach to the treatment of women with infertility caused by thin endometrium which is refractory to the standard treatment. Further research is needed to provide the opportunity for the women with refractory thin endometrium to conceive without surrogacy.

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About the authors

Z. N Efendieva

M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: efendievaz@yandex.ru
postgraduate at the Department of Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Professional Education 2-4, Bolshaya Pirogovskaya str., Moscow, 119991, Russian Federation

I. A Apolikhina

I.M. Sechenov First MSMU of Ministry of Health of Russia (Sechenov University); National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Perinatology and Reproductology

Email: nondoc555@yahoo.com
MD, professor, Head of Department of Aesthetic Gynecology and Rehabilitation. рrofessor of the Department of Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Professional Education 117997 Russia, Moscow, Ac. Oparina str. 4

E. A Kalinina

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: ekalinina@oparina4.ru
MD, professor, Head of Department of Assistive technologies in infertility treatment 4, Oparina str., Moscow, 117997, Russian Federation

T. A Fedorova

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: tfyodorova@oparina4.ru
MD, professor, Head of Transfusional Department of National Medical Research Center for Obstetrics, Gynecology and Perinatology named 4, Oparina str., Moscow, 117997, Russian Federation

E. M Bakuridze

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: ebakuridze@oparina4.ru
transfusiologist, Head of the Department of Extracorporal methods of treatment and detoxication 4, Oparina str., Moscow, 117997, Russian Federation

D. M Belousov

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: dbelousov@oparina4.ru
PhD, doctor of the Department of the Functional diagnosis 4, Oparina str., Moscow, 117997, Russian Federation

T. K.H Fathudinov

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia; FSBI «Research Institute of Human Morphology»

Email: tfat@yandex.ru
PhD, MD, leading researcher, Laboratory of regenerative medicine, Deputy Director for Scientific development 4, Oparina str., Moscow, 117997, Russian Federation

G. T Sukhikh

M. Sechenov First Moscow State Medical University, Ministry of Health of Russia; Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: gtsukhih@mail.ru
MD, PhD, professor, Academician of Russian Academy of Sciences, Director 4, Oparina str., Moscow, 117997, Russian Federation

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