The use of high-intensity focused ultrasound in the treatment of genital forms of scleroatrophic lichen


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Abstract

The article presents an overview of the use of high-intensity focused ultrasound (HIFU) in the treatment of vulvar lichen sclerosus. The paper provides the definition and principle of operation of HIFU, analyzes studies that show the effectiveness and safety of this method. The f irst attempts to use HIFU in medicine were made in the field of neurosurgery in the United States in the early 1940s by Professor William Fry. In the 1950s, his laboratory designed a device for the use of focused ultrasound in experimental neurosurgery, namely, to cause local destructions of a certain size in the deep structures in the brain of animals. In the USSR, the research on the clinical application of focused ultrasound started in the early 1970s at the Acoustics Institute of the USSR Academy of Sciences (AKIN), Sechenov Institute of Evolutionary Physiology and Biochemistry, Institute of Human Brain, Pavlov Institute of Physiology and a number of other scientific institutions. Nowadays, HIFU can be used not only in neurosurgery, for example, to control neuropathic pain, intracerebral hemorrhages and Alzheimer’s disease, but also in many other fields of medicine (dermatology, gynecology, oncology, mammology, etc.) as surgical treatment of malignant tumors in oncology, surgery of uterine fibromyoma, destruction of prostate tumors, exposure to tissues located behind the chest, or intracerebral tissues without performing craniotomy. Conclusion: It can be assumed that the treatment of vulvar lichen sclerosus with high-intensity focused ultrasound can be an alternative to the therapy with topical corticosteroids, as their frequent and prolonged use can lead to skin thinning, ricochet reactions, scarring of tissues, reactivation of fungal and papillomavirus infections. HIFU is a new and promising method for the treatment of vulvar lichen sclerosus and requires further randomized controlled trials

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About the authors

Tatiana A. Teterina

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: t_teterina@oparina4.ru
PhD, obstetrician-gynecologist of the Department of Aesthetic Gynecology and Rehabilitation 117997, Russia, Moscow, Oparina str., 4

Maria P. Ishchuk

N.N. Burdenko Voronezh Medical State University Ministry of Health of Russia

Email: marumariyaish@gmail.com
pediatrician 394036, Russia, Voronezh, Studencheskaya str., 9

Marina O. Ramazanova

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: marlnaramazanova@yandexru
the 2nd year resident 117997, Russia, Moscow, Oparina str., 4

Inna A. Apolikhina

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University (Sechenov University) Ministry of Health of Russia

Email: i_apolikhina@oparina4.ru
MD, Head of the Department of Aesthetic Gynecology and Rehabilitation; Professor of the Department of Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Professional Education; President of European Association for Genital Aesthetic Medicine and Plastic Surgery (EAGAMPS 117997, Russia, Moscow, Oparina str., 4

References

  1. Krapf J.M., Mitchell L, Holton M.A., Goldstein A.T. Vulvar lichen sclerosus: current perspectives. Int. J. Women's Health. 2020; 12: 11-20. https://dx.doi.org/10.2147/IJWH.S191200.
  2. Соколова А.В., Аполихина И.А. Лечение склерозирующего лихена наружных половых органов у женщин: от стандартов к инновациям. Акушерство и гинекология. 2020; 7: 37-46. https://dx.doi.org/10.18565/aig.2020.7.37-46.
  3. Аполихина И.А., Соколова А.В., Балашов И.С., Чернуха Л.В., Ермакова Е.И. Лечение склерозирующего лихена вульвы фракционным С02-лазером: проспективное клиническое исследование. Акушерство и гинекология: новости, мнения, обучение. 2020; (8(2): 48-58.
  4. Гаврилов Л.Р. Фокусированный ультразвук высокой интенсивности в медицине. М.: Фазис; 2013. 656 с.
  5. Von Krogh G, Dahlman-Ghozlan K., Syrjdnen S. Potential human papillomavirus reactivation following topical corticosteroid therapy of genital lichen sclerosus and erosive lichen planus. J. Eur. Acad. Dermatol. Venereol. 2002; 16(2): 130-3. https://dx.doi.org/10.1046/j.1468-3083.2002.00420.x.
  6. Neill S.M., Tatnall F.M., Cox N.H. Guidelines for the management of lichen sclerosus. Br. J. Dermatol. 2002; 147(4): 640-9. https://dx.doi.org/10.1046/j.1365-2133.2002.05012.x.
  7. Tran D.A., Tan X., Macri C.J., Goldstein A.T., Fu S.W. Lichen sclerosus: An autoimmunopathogenic and genomic enigma with emerging genetic and immune targets. Int. J. Biol. Sci. 2019; 15(7):1429-39. https://dx.doi.org/10.7150/ijbs.34613.
  8. Kovatcheva R., Guglielmina J.N., Abehsera M., Boulanger L., Laurent N., Poncelet E. Ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma - a multicenter experience. J. Ther. Ultrasound. 2015; 3(1):1. https://dx.doi.org/10.1186/s40349-014-0022-3.
  9. Соколова А.В., Аполихина И.А., Зайцев Н.В., Чернуха Л.В. Клиникоморфологические стадии склерозирующего лихена вульвы у женщин. Гинекология. 2020; 22(4): 22-7.
  10. Зароченцева Н.В., Джиджихия Л.К. Интраэпителиальная неоплазия вульвы: современный взгляд на проблему. Российский вестник акушера-гинеколога. 2020; 20(1): 44-53.
  11. Siedek F., Yeo S.Y., Heijman E., Grinstein O., Bratke G. et al. Magnetic Resonance- Guided High- Intensity Focused Ultrasound (MR-HIFU): Technical Background and Overview of Current Clinical Applications (Part 1). Rofo. 2019; 191(6): 522-30. https://dx.doi.org/10.1055/a-0817-5645.
  12. Zhou W, Zhu L., Zhou H., Shen K., Lang J., Cui Q., Shi H. The efficacy of high-intensity, focused ultrasound treatment for non-neoplastic epithelial disorders of the vulva. Cell. Mol. Biol. (Noisy-le-grand). 2016; 62(4): 111-5.
  13. Shi H.H., Zhu L., Yang Y., Jin H.M., Li R.Z., Liang Z.Q., Lang J.H. Multicenter randomized clinical study of high-intensity focused ultrasound and cortical hormone in the treatment of non-neoplastic epithelial disorders of vulva. Zhonghua Yi Xue Za Zhi. 2013; 93(41): 3291-3.
  14. Gautam M.M., Singh V., Nadkarni N.J., Patil S.P Anogenital lichen sclerosus. Indian J. Sex. Transm. Dis. AIDS. 2020; 41(1): 1-9. https://dx.doi.org/10.4103/ijstd.IJSTD_49_17.
  15. Kirtschig G., Becker K., Gunthert A., Jasaitiene D., Cooper S., Chi C.C. et al. Evidence-based (S3) guideline on (anogenital) lichen sclerosus. J. Eur. Acad. Dermatol. Venereol. 2015; 29(10): e1-43. https://dx.doi.org/10.1111/jdv.13136.
  16. Cooper S.M., Gao Х.-H., Powel J.J., Wojnarovska F. Does treatment of vulvar lichen sclerosus influence its prognosis? Arch Dermatol. 2004; 140(6); 702-6. https://dx.doi.org/10.1001/archderm.140.6.702.
  17. Wu C., Zou M., Xiong Y., Wang L., Chen H., Fan Y., Li C. Short- and long-term efficacy of focused ultrasound therapy for non-neoplastic epithelial disorders of the vulva. BJOG. 2017; 124(Suppl. 3): 87-92. https://dx.doi.org/10.1111/1471-0528.14747.
  18. Хамитова Г.В. Оценка туморицидного эффекта ультразвука в экспериментальных и клинических исследованиях. Креативная хирургия и онкология. 2011; 1: 96-100.

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