Embryo tranfer at zygote stage in patients with failed embryonic development in previous in vitro fertilization programs
- Authors: Nazarenko T.A.1, Martirosyan Y.O.1, Krasnova V.G.1, Biryukova A.M.1, Sokolova J.V.1
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Affiliations:
- Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- Issue: No 6 (2022)
- Pages: 83-89
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/249545
- DOI: https://doi.org/10.18565/aig.2022.6.83-89
- ID: 249545
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Abstract
Objective: Assessment of the effectiveness of embyo transfer into uterine cavity at the zygote stage in patients with multiple IVF/ICSI failures in history and the absence of embryonic cleavage cultured in vitro. Materials and methods: The study included 37 patients. The mean age of patients was 38.3 (3.3) лет, and infertility duration was 6.1 (2.3) years. Idiopathic infertility was a major nosologic form of infertility. Independently of the chosen ovarian stimulation protocol and the used type of gonadotropins, the absence of embryos that could be offered for transfer and stoppage of embryonic development took place in all attempts. In 37 women in the study group, embryo transfer into the uterine cavity was performed on day 1 after transvaginal ovarian puncture, immediately after fertilization was confirmed. Results: The average number of IVF/ICSI attempts in history of the patients included in the study was 4.2 (1.6). The retrospective analysis confirmed that the parameters of early embryo development was impaired in all patients in the study group. Pregnancy rate in the group of women below 40 years was 45.0% (9/20), and 5.8% (1/17) in the group of patients of late reproductive age. Conclusion: It is supposed that in vitro embryo culture may be one of the cause of impaired embryo development and early embryonic developmental arrest. Due to this, embryo transfer strategy into the uterine cavity at zygote stage, can influence physiological preimplantation development and as a result lead to the onset of pregnancy in difficult clinical situations, when embryos stop developing. This method can be effective for the patients of young age, who mainly have euploid oocytes.
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About the authors
Tatiana A. Nazarenko
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: t_nazarenko@oparina4.ru
Dr. Med. Sci., Professor, Director of Institute of Reproductive Medicine
Yana O. Martirosyan
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: ya_martirosyan@oparina4.ru
Researcher at the Scientific and Educational Center for ART with the Clinical Division named after F. Paulsen
Valeria G. Krasnova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: lkrasnova27@gmail.com
clinical resident, Scientific and Educational Center for ART with the Clinical Division named after F. Paulsen
Almina M. Biryukova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: a_birukova@oparina4.ru
PhD, gynecologist at Scientific and Clinical Department of ART named after F. Paulsen
Julia V. Sokolova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: julietsok@gmail.com
embryologist
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