POSSIBILITIES OF THERAPY FOR HPV-ASSOCIATED CHRONIC CERVICITIS IN WOMEN
- Authors: Maltseva L.I.1, Farrakhova L.N.2
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Affiliations:
- Kazan State Medical Academy, Branch, Russian Medical Academy of Continuing Postgraduate Education
- Medical Center, OOO "Meditsina Krasoty" (The Medicine of Beauty)
- Issue: No 6 (2017)
- Pages: 127-134
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/329724
- DOI: https://doi.org/10.18565/aig.2017.6.127-34
- ID: 329724
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Abstract
Objective. To study the possibilities of the diagnosis and treatment of chronic cervicitis in women with human papillomavirus (HPV) infection in relation to the biomarkers of proliferation and carcinogenesis in the cervical epithelium. Subjects and methods. 245 female patients with HPV-associated chronic cervicitis and 20 healthy women were examined for the ratio of the urinary estrogen metabolites 2-OHE1 to 16α-ОНЕ1 (Estramet test system) and the expression of p16ink4α in the cervical epithelium by immunocytochemical assay. For the treatment of HPV-associated cervicitis, 30patients used a combination of promisan and interferon-α or Panavir; 30 more patients received only Panavir or interferon-α. Results. The oncoprotein р16іпк4α expression and the low 2-ОНЕ1/16α-ОНЕ1 ratio were found to be directly related to the long-term persistence of HPV and the progressive course of cervical pathology. Conclusion. Six-month combination treatment with promisan and interferon-α led to normalization of the exchange of the estrogen metabolites, the elimination of HPV, and regression of an inflammatory response from CIN I-II to the cytological normal value in 86.7-93.3% of the women.
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About the authors
Larisa Ivanovna Maltseva
Kazan State Medical Academy, Branch, Russian Medical Academy of Continuing Postgraduate Education
Email: laramalc@mail.ru
doctor of medical sciences, Professor, Head of Department of obstetrics and gynecology № 1 Kazan 420012, Mushtari str. 11, Russia
Liliya Nailevna Farrakhova
Medical Center, OOO "Meditsina Krasoty" (The Medicine of Beauty)
Email: lifara@mail.ru
candidate of medical sciences, obstetrician-gynecologist Kazan 420012, Mushtari str. 11, Russia
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