PROBIOTICS FOR PROPHYLAXIS OF VULVOVAGINAL CANDIDIASIS RELAPSES (RESULTS OF THE INTERNATIONAL MULTICENTER OPEN-LABEL REVOLACT STUDY)


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Objective. To evaluate efficacy and safety of L. casei rhamnosus Doderleini strain (lactogynal, vaginal capsules), for prevention of recurrences of vulvovaginal candidiasis in the multicenter international multicenter open-label REVOLACT study. Subject and methods. After antimycotic therapy using sertaconazole (zalain, suppository 300 mg once and 2% cream 2 times a day for 8 days), female patients from main group (74 women) received intravaginal lactobacillus lactogynal within 21 days; the comparison group (80 women) of patients did not receive any probiotics. The period of dynamic observation of patients was 5 months, during which the registration of recurrences of vulvovaginal candidiasis (reporter and laboratory confirmed) was conducted. Results. Results demonstrate the effectiveness of combined therapy using sertaconazole (zalain, suppository 300 mg once and 2% cream 2 times a day for 8 days) followed by the application lactogynal within 21 days to prevent recurrence of vulvovaginal candidiasis compared to monotherapy with sertaconazole (zalain, suppository 300 mg once and 2% cream 2 times a day for 8 days). Time before relapse of vulvovaginal candidiasis after therapy with sertaconazole in the lactogynal group was 148.45±2.04 days and 137.40±4.41 days in the comparison group. The incidence of vulvovaginal candidiasis in the lactogynal group was significantly lower: 12 patients (16.2%) vs. 24 patients (30%) in the comparison group (p <0.05). Conclusion. Study demonstrates the efficacy and safety of L. casei rhamnosus Doderleini culture (lactogynal, vaginal capsules) in the complex treatment of vulvovaginal candidiasis for the prevention of relapse.

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作者简介

Nadezhda Bashmakova

Ural Research Institute of Maternal and Infant Care

MD, professor, director Yekaterinburg, Repina str. 1, Russia

Natalia Volkova

Consultative and Diagnostic Center of Pechersky district

head of the gynecological department Kiev 01042 L. Ukrainka Boulevard, 36-V, Ukraine

Elena Gnatko

City Maternity Hospital № 6

MD, Professor Kiev 02125, P. Zaporozhets str. 26-A, Ukraine

Irina Dankova

Consultative and Diagnostic Center of Pechersky district

candidate of medical science, senior researcher Kiev 01042 L. Ukrainka Boulevard, 36-V, Ukraine

Yulia Dobrokhotova

N.I. Pirogov Russian National Research Medical University

MD, Professor, head of the Department Moscow 117997, Ostrovityanova str. 1, Russia

Lyudmila Karakhalis

Regional Clinical Hospital № 2

MD, professor Krasnodar 350012, Krasniy Partizan str. 6/2, Russia

Larisa Maltseva

Kazan State Medical Academy

Head of the Obstetrics and Gynecology Department One Kazan 420012, Mushtari str. 11, Russia

Yana Nadeliaeva

Scientific Center for Family Health and Human Reproduction

Ph.D., researcher of the laboratory of gynecological endocrinology Irkutsk 644003, Timiryazeva str. 16, Russia

Valentin Potapov

City Maternity Hospital № 1

MD, Professor Dnepropetrovsk 49000, Lenina str. 2, Ukraine

Olga Serova

Moscow Regional Perinatal Center

chief physician Balashikha 143900, sh. Enthusiasts, 12, Russia

Larissa Suturina

Scientific Center for Family Health and Human Reproduction

MD, professor, head of the reproductive department Irkutsk 644003, Timiryazeva str. 16, Russia

Marina Tarasova

D.O. Ott Scientific Research Institute of Obstetrics and Gynecology

Email: tarasova@ott.ru
MD, Professor St. Petersburg 199034, Mendeleevskaya line, 3, Russia

Tatyana Tatarchuk

City Clinical Endocrinology Center

MD, Professor Kyiv 01034, Reitarskaya str. 22, Ukraine

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