The practice of prescribing antimicrobials to pregnant women with concomitant somatic diseases
- Authors: Korobkov N.A.1, Bakulina N.V.1, Repina M.A.1, Arnt O.S.1
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Affiliations:
- I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
- Issue: No 2 (2023)
- Pages: 118-124
- Section: Exchange of Experience
- URL: https://journals.eco-vector.com/0300-9092/article/view/340782
- DOI: https://doi.org/10.18565/aig.2022.308
- ID: 340782
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Abstract
Background: Clinical and pharmacoepidemiological studies have been conducted to optimize the use of antibacterial drugs in pregnant women with somatic diseases.
Objective: To analyze the prescription of systemic antimicrobial drugs to pregnant women with concomitant somatic diseases in routine medical practice.
Materials and methods: A non-interventional retrospective analysis of data from different forms of primary medical documentation was carried out in 144 pregnant women who received systemic antimicrobial therapy for somatic diseases.
Results: The investigation revealed the irrational use of antimicrobial drugs in pregnant women with concomitant somatic diseases: the prescription of identical antibiotics for somatic diseases and peripartum infections; the unreasonable use of preventive cycles of antibacterial drugs, the excessive use of restricted antibiotics according to the WHO AWaRe classification database (third-generation cephalosporins) and inhibitor-protected β-lactam agents.
Conclusion: To date, the prescription of systemic antimicrobial drugs to pregnant women with concomitant somatic diseases is rational only in 68.2% of cases.
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About the authors
Nikolay A. Korobkov
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Author for correspondence.
Email: nikolai_korobkov@mail.ru
ORCID iD: 0000-0001-7279-2535
SPIN-code: 4191-3581
PhD, Associate Professor at the S.N. Davydov Department of Obstetrics and Gynecology
Russian Federation, Saint PetersburgNatalia V. Bakulina
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Email: nikolai_korobkov@mail.ru
ORCID iD: 0000-0003-4075-4096
SPIN-code: 9503-8950
Dr. Med. Sci., Professor, Head of the Department of Internal Medicine, Clinical Pharmacology and Nephrology, Vice-Rector for Science and Innovation
Russian Federation, Saint PetersburgMargarita A. Repina
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Email: nikolai_korobkov@mail.ru
Dr. Med. Sci., Professor
Russian Federation, Saint PetersburgOlga S. Arnt
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Email: nikolai_korobkov@mail.ru
ORCID iD: 0000-0003-1565-2012
SPIN-code: 1482-0917
PhD, Associate Professor at the S.N. Davydov Department of Obstetrics and Gynecology
Russian Federation, Saint PetersburgReferences
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