The practice of prescribing antimicrobials to pregnant women with concomitant somatic diseases

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Background: Clinical and pharmacoepidemiological studies have been conducted to optimize the use of antibacterial drugs in pregnant women with somatic diseases.

Objective: To analyze the prescription of systemic antimicrobial drugs to pregnant women with concomitant somatic diseases in routine medical practice.

Materials and methods: A non-interventional retrospective analysis of data from different forms of primary medical documentation was carried out in 144 pregnant women who received systemic antimicrobial therapy for somatic diseases.

Results: The investigation revealed the irrational use of antimicrobial drugs in pregnant women with concomitant somatic diseases: the prescription of identical antibiotics for somatic diseases and peripartum infections; the unreasonable use of preventive cycles of antibacterial drugs, the excessive use of restricted antibiotics according to the WHO AWaRe classification database (third-generation cephalosporins) and inhibitor-protected β-lactam agents.

Conclusion: To date, the prescription of systemic antimicrobial drugs to pregnant women with concomitant somatic diseases is rational only in 68.2% of cases.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Nikolay Korobkov

I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

Хат алмасуға жауапты Автор.
Email: nikolai_korobkov@mail.ru
ORCID iD: 0000-0001-7279-2535
SPIN-код: 4191-3581

PhD, Associate Professor at the S.N. Davydov Department of Obstetrics and Gynecology

Ресей, Saint Petersburg

Natalia Bakulina

I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

Email: nikolai_korobkov@mail.ru
ORCID iD: 0000-0003-4075-4096
SPIN-код: 9503-8950

Dr. Med. Sci., Professor, Head of the Department of Internal Medicine, Clinical Pharmacology and Nephrology, Vice-Rector for Science and Innovation

Ресей, Saint Petersburg

Margarita Repina

I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

Email: nikolai_korobkov@mail.ru

Dr. Med. Sci., Professor

Ресей, Saint Petersburg

Olga Arnt

I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

Email: nikolai_korobkov@mail.ru
ORCID iD: 0000-0003-1565-2012
SPIN-код: 1482-0917

PhD, Associate Professor at the S.N. Davydov Department of Obstetrics and Gynecology

Ресей, Saint Petersburg

Әдебиет тізімі

  1. Aryee A., Price N. Antimicrobial stewardship – can we afford to do without it? Br. J. Clin. Pharmacol. 2015; 79(2): 173-81. https://dx.doi.org/10.1111/bcp.12417.
  2. WHO. WHO recommendations for prevention and treatment of maternal peripartum infections. Geneva: WHO; 2015.
  3. Ministry of Health of the Russian Federation. Clinical guidelines. Urinary tract infection in pregnancy. Мoscow; 2022. (in Russian).
  4. Huttner A., Verhaegh E.M., Harbarth S., Muller A.E., Theuretzbacher U., Mouton J.W. Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials. J. Antimicrob. Chemother. 2015; 70(9): 2456-64. 1 https://dx.doi.org/0.1093/jac/dkv147.
  5. Palagin I.S., Sukhorukova M.V., Dekhnich A.V., Edelstein M.V., Perepanova T.S., Kozlov R.S. et al. Antimicrobial resistance of pathogens causing community – acquired urinary tract infections in Russia: results of the multicenter study "DARMIS – 2018". Clinical Microbiology and Antimicrobial Chemotherapy. 2019; 21(2): 134-46. (in Russian).
  6. Ministry of Health of the Russian Federation. Order N 572n dated November 1, 2012 "On approval of the procedure for providing medical care in the field of obstetrics and gynecology (except the use of assisted reproductive technologies)" (registered with the Ministry of Justice of Russia on April 2, 2013 N 27960). (in Russian).
  7. Ministry of Health of the Russian Federation. Order N 572n dated November 1, 2012 "On approval of the procedure for providing medical care in the field of obstetrics and gynecology (except the use of assisted reproductive technologies)" (registered with the Ministry of Justice of Russia on April 2, 2013 N 27960). (in Russian).
  8. Ministry of Health of the Russian Federation. Clinical guidelines. Acute respiratory viral infections in adults. Moscow; 2021. (in Russian).
  9. Ministry of Health of the Russian Federation. Clinical guidelines. Bronchitis. Moscow; 2021. (in Russian).
  10. Ministry of Health of the Russian Federation. Clinical guidelines. Community-acquired pneumonia in adults. Moscow; 2022. (in Russian).
  11. Macones G.A., Cleary K.L., Parry S., Stamilio D.M., Cahill A.G., Odibo A.O., Rampersad R. The timing of antibiotics at cesarean: A randomized controlled trial. Am. J. Perinatol. 2012; 29(4): 273-6. https://dx.doi.org/ 10.1055/s-0031-1295657.
  12. WHO model list of essential medicines. 20th list (March 2017) Geneva: World Health Organization; 2017. Available at: www.who.int/publications/i/item/2021-aware-classification (Accessed 03.01.2023).
  13. Mehta N., Chen K., Hardy E., Powrie R. Respiratory disease in pregnancy. Best. Pract. Res. Clin. Obstet. Gynaecol. 2015; 29(5): 598-611. https://dx.doi.org/ 10.1016/j.bpobgyn.2015.04.005.
  14. Stinson L.F., Payne M.S., Keelan J.A. Planting the seed: origins, composition, and postnatal health significance of the fetal gastrointestinal microbiota. Crit. Rev. Microbiol. 2017; 43(3): 352-69. https://dx.doi.org/10.1080/ 1040841X.2016.1211088.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
2. Figure 1. Structure of antimicrobial chemotherapy for urinary tract infections in pregnant women (n=98), %

Жүктеу (56KB)
3. Figure 2. Bacteriological structure of urinary tract infections during pregnancy (n=80), %

Жүктеу (44KB)
4. Figure 3. The total frequency of insensitivity of isolated bacterial pathogens to the main antimicrobial drugs used in the treatment of urinary tract infections in pregnant women, %

Жүктеу (44KB)
5. Figure 4. Structure of antimicrobial chemotherapy for respiratory infections in pregnant women (n=43), %

Жүктеу (48KB)
6. Figure 5. Bacteriological structure of respiratory infections in pregnant women (n=43), %

Жүктеу (53KB)

© Bionika Media, 2023