Portal vein thrombosis while taking a combined oral contraceptive after experienced coronavirus infection
- Authors: Shklyaev A.E.1, Fatkhieva A.R.1, Bessonov A.G.2, Meleshkina M.V.2, Zykov S.Y.2
-
Affiliations:
- Izhevsk State Medical Academy, Ministry of Health of Russia
- First Republican Clinical Hospital, Ministry of Health of the Udmurt Republic
- Issue: No 2 (2023)
- Pages: 165-170
- Section: Clinical Notes
- URL: https://journals.eco-vector.com/0300-9092/article/view/340805
- DOI: https://doi.org/10.18565/aig.2023.5
- ID: 340805
Cite item
Open Access
Access granted
Abstract
Background: Contraceptives are an important component of women’s reproductive health care, as they not only reduce the number of unwanted pregnancies, but also improve reproductive function. However, oral contraceptives are known to increase the risk of venous thromboembolism. This risk is increased by infection with the COVID-19 virus that predisposes patients to both venous and arterial thrombosis as a result of excessive inflammation, platelet activation, aggravated endothelial dysfunction, and congestive events. If these patients have hereditary thrombophilia, the risk of venous thromboembolism becomes fatal.
Case report: The paper describes a clinical case of a patient with total portal vein thrombosis, who have been taking oral contraceptives for a long time and recovering from the novel coronavirus infection. Studying the blood coagulation system and folate cycle genes, by using PCR, has revealed a gene mutation in the plasminogen activator inhibitor (serpine). The authors demonstrate the data of spiral computed tomography of the abdominal organs, as well as changes in laboratory parameters.
Conclusion: A balanced approach is required when prescribing combined oral contraceptives during the COVID-19 pandemic, especially in women with prothrombotic mutations.
Full Text
About the authors
Alexey E. Shklyaev
Izhevsk State Medical Academy, Ministry of Health of Russia
Email: shklyaevaleksey@gmail.com
ORCID iD: 0000-0003-4479-508X
Dr. Med. Sci., Professor, Professor at the Department of Faculty Therapy with courses of endocrinology and hematology
Russian Federation, IzhevskAlina R. Fatkhieva
Izhevsk State Medical Academy, Ministry of Health of Russia
Author for correspondence.
Email: alifathi98@mail.ru
student
Russian Federation, IzhevskAlexey G. Bessonov
First Republican Clinical Hospital, Ministry of Health of the Udmurt Republic
Email: besson_alex@mail.ru
PhD, Head of the Gastroenterology Department
Russian Federation, IzhevskMaria V. Meleshkina
First Republican Clinical Hospital, Ministry of Health of the Udmurt Republic
Email: alifathi98@mail.ru
gastroenterologist
Russian Federation, IzhevskSergey Yu. Zykov
First Republican Clinical Hospital, Ministry of Health of the Udmurt Republic
Email: sergeyzykov1977@gmail.com
radiologist
Russian Federation, IzhevskReferences
- Samant H., Asafo-Agyei K.O., Garfield K. Portal vein thrombosis. In: StatPearls. Treasure Island (FL): StatPearls Publishing; September 14, 2021.
- Valeriani E., Riva N., Di Nisio M., Ageno W. Splanchnic vein thrombosis: current perspectives. Vasc. Health Risk Manag. 2019; 15: 449-61. https://dx.doi.org/10.2147/VHRM.S197732.
- Gialeraki A., Valsami S., Pittaras T., Panayiotakopoulos G., Politou M. Oral contraceptives and HRT risk of thrombosis. Clin. Appl. Thromb. Hemost. 2018; 24(2): 217-25. https://dx.doi.org/10.1177/1076029616683802.
- Dragoman M.V., Tepper N.K., Fu R., Curtis K.M., Chou R., Gaffield M.E. A systematic review and meta-analysis of venous thrombosis risk among users of combined oral contraception. Int. J. Gynaecol. Obstet. 2018; 141(3): 287-94. https://dx.doi.org/10.1002/ijgo.12455.
- Kazantsev A.N. Thrombectomy vs conservative therapy in patients with COVID-19. Cardiovascular Therapy and Prevention. 2021; 20(4): 2931. (in Russian). https://dx.doi.org/10.15829/1728-8800-2021-2931.
- Makatsariya A.D., Akinshina S.V. Thrombosis of unusual sites and thrombophilia. Obstetrics, Gynecology and Reproduction. 2014; 8(2): 97-111 (in Russian)
- Kuznetsov M.R., Papysheva O.V. Menopausal hormone therapy and venous thromboembolic complications: what is the relationship? Doctor.Ru. 2019; (11): 68-73. (in Russian). https://dx.doi.org/10.31550/ 1727-2378-2019-166-11-68-73.
- Markelov M.I., Beznoschenko O.S., Ivanets T.Yu., Pyregov A.V., Esayan R.M., Gavrilova T.Yu., Krechetova L.B. Features of the plasma hemostasis system in patients with the novel coronavirus infection COVID-19. Obstetrics and Gynecology. 2020; (9): 138-44. (in Russian). https://dx.doi.org/10.18565/ aig.2020.9.138-144.
- Limanova O.A., Gromova O.A., Fedotova L.E. Combined oral contraception and treatment of new coronavirus infection (COVID-19): drug interaction issues. Pharmacokinetics and Pharmacodynamics. 2020; (3): 30-9. (in Russian). https://dx.doi.org/10.37489/2587-7836-2020-3-30-39.
- Kow C.S., Mustafa Z.U., Hasan S.S. The use of combined hormonal contraceptives amid the COVID-19 pandemic. Eur. J. Contracept. Reprod. Health Care. 2021; 26(1): 85-6. https://dx.doi.org/10.1080/13625187.2020.1849618.
- Shklyaev A.E., Fatkhieva A.R., Bessonov A.G., Zykov S.Yu., Malakhova I.G. Liver cirrhosis due to thrombosis of the portal, superior mesenteric and splenic veins: a five-year dynamics. Medical News of North Caucasus. 2021; 16(4): 427-9. (in Russian). https://dx.doi.org/10.14300/mnnc.2021.16104.
- Shklyaev A.E., Bessonov A.G., Chushyalova D.A., Mikhailova M.D., Meleshkina M.V. Features of the course of coronovirus infection against the background of pseudomembranous colitis in the early postpartum period: clinical observation. Obstetrics and Gynecology. 2021; (9): 232-6. (in Russian). https://dx.doi.org/10.18565/aig.2021.9.232-236.
Supplementary files
