Genital candidiasis in the pattern of opportunistic vaginal infections. The principles of laboratory diagnosis and the value of monitoring of fungal susceptibility to antimycotics


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Abstract

The results of 11-year monitoring of the species composition and antimycotic susceptibility of yeast fungi isolated from the vagina of reproductive-age women in 1997 to 2007. The fungal isolation rate in high-risk women increased from 3-4% in the 1960-1970s to 17-20% in the early 21st century. Candida albicans amounted to 83.7-86.0%; C. non-albicans did 14-16.3%, without showing a significant downward or upward trend. The procedure reproducing the NCCLS standard M-27-A2 was used to ascertain susceptibility to 6 antimycotics in 580 isolates. The study has demonstrated that more than 90% of the fungi C. albicans and C. parapsilosis are currently sensitive to imidazoles and triazoles. Among the "problem" non-albicans species (C. glabrata, C. krusei), the insusceptible strains had mainly a dose-dependent susceptibility that may be overcome, by increasing the course dosage of an agent. The determination of fungal susceptibility in wide clinical practice is presently unwarranted.

About the authors

A S Ankirskaya

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

V V Muravyeva

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

T G Mironova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

T Ye Koroleva

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

L A Lyubasovskaya

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

T E Karapetyan

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

G R Bairamova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

References

  1. Выборнова И. В. // Пробл. мед. микол. - 2006. - Т. 8, № 2. - С. 28.
  2. Горбунова Н. А., Тихонова Л. В. // Вакцинология 2008. Совершенствование иммунобиологических средств профилактики, диагностики и лечения инфекционных болезней: Тезисы Всероссийской науч.-практ. конф. - М., 2008. - С. 40-41.
  3. Стрижаков А. Н., Давыдов А. И., Баев О. Р., Буданов П. В. Генитальные инфекции. - М., 2003.
  4. Al-Adnani, Sebire N. J. // Best Pract. Clin. Obstetr. and Gynaecol. - 2007. - Vol. 21, № 3. - P. 505-521.
  5. Alexander B. D., Byrne T. C., Smith K. L. et al. // J. of Clin. Microbiol. - 2007. - Vol. 45, № 3. - P. 698-706.
  6. Costa M., Passos X. S., Mizanda A. T. B. et al. // J. Mycopathol. - 2004. - Vol. 157. - P. 43-47.
  7. Martinos M. D., Lozano-Chin M., Rex J. H. // J. Clin. Infect. Dis. - 1997, Vol. 25. - P. 843-846.
  8. Clinical Laboratory Standards institute. Reference Method for Broth Dilution Antifungal Susceptibiliity Testing of Yeasts; Approved Standard. - 2nd Ed. M 27-A2. - 2002. - SLSI/NCCLS, Wayne, Pa, USA.
  9. Perea S., Lopes-Ribot J. L., Krkpatrick W. R. et al. // Antimicrob. Agents Chemother. - 2001. - Vol. 45. - P. 2676-2684.
  10. Redding S. W., Kirckpatrick W. R., Saville S. et al. // J. Clin. Microbiol. - 2003. - Vol. 41. - P. 619-622.
  11. Rex J. H., Rinald M. G., Pfaller M. A. // Antimicrob. Agents Chemoter. - 1995. - Vol. 39. - P. 1-8.
  12. Richter S. S., Galask R. P., Messer S. A. et al. // J. Clin. Microbiol. - 2005. - Vol. 43. - P. 2155-2162.
  13. Sobel J. D., Zervos M., Reed B. D. et al. // Antimicrob. Ag. Chemother. - 2003. - N 1. - P. 34-38.

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