Genital candidiasis in the pattern of opportunistic vaginal infections. The principles of laboratory diagnosis and the value of monitoring of fungal susceptibility to antimycotics


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The results of 11-year monitoring of the species composition and antimycotic susceptibility of yeast fungi isolated from the vagina of reproductive-age women in 1997 to 2007. The fungal isolation rate in high-risk women increased from 3-4% in the 1960-1970s to 17-20% in the early 21st century. Candida albicans amounted to 83.7-86.0%; C. non-albicans did 14-16.3%, without showing a significant downward or upward trend. The procedure reproducing the NCCLS standard M-27-A2 was used to ascertain susceptibility to 6 antimycotics in 580 isolates. The study has demonstrated that more than 90% of the fungi C. albicans and C. parapsilosis are currently sensitive to imidazoles and triazoles. Among the "problem" non-albicans species (C. glabrata, C. krusei), the insusceptible strains had mainly a dose-dependent susceptibility that may be overcome, by increasing the course dosage of an agent. The determination of fungal susceptibility in wide clinical practice is presently unwarranted.

Sobre autores

A Ankirskaya

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

V Muravyeva

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

T Mironova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

T Koroleva

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

L Lyubasovskaya

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

T Karapetyan

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

G Bairamova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

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