Genital candidiasis in the pattern of opportunistic vaginal infections. The principles of laboratory diagnosis and the value of monitoring of fungal susceptibility to antimycotics

A S Ankirskaya; Анкирская Алла Семеновна; V V Muravyeva; Муравьева В В; T G Mironova; Миронова Т Г; T Ye Koroleva; Королева Т Е; L A Lyubasovskaya; Любасовская Л А; T E Karapetyan; Карапетян Т Э; G R Bairamova; Байрамова Г Р

Genital candidiasis in the pattern of opportunistic vaginal infections. The principles of laboratory diagnosis and the value of monitoring of fungal susceptibility to antimycotics

作者: Ankirskaya AS¹, Muravyeva VV¹, Mironova TG¹, Koroleva TY.¹, Lyubasovskaya LA¹, Karapetyan TE¹, Bairamova GR¹
隶属关系:
1. Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow
期: 编号 5 (2009)
页面: 31-37
栏目: Articles
URL: https://journals.eco-vector.com/0300-9092/article/view/246132
ID: 246132

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The results of 11-year monitoring of the species composition and antimycotic susceptibility of yeast fungi isolated from the vagina of reproductive-age women in 1997 to 2007. The fungal isolation rate in high-risk women increased from 3-4% in the 1960-1970s to 17-20% in the early 21st century. Candida albicans amounted to 83.7-86.0%; C. non-albicans did 14-16.3%, without showing a significant downward or upward trend. The procedure reproducing the NCCLS standard M-27-A2 was used to ascertain susceptibility to 6 antimycotics in 580 isolates. The study has demonstrated that more than 90% of the fungi C. albicans and C. parapsilosis are currently sensitive to imidazoles and triazoles. Among the "problem" non-albicans species (C. glabrata, C. krusei), the insusceptible strains had mainly a dose-dependent susceptibility that may be overcome, by increasing the course dosage of an agent. The determination of fungal susceptibility in wide clinical practice is presently unwarranted.

关键词

Candida albicans, Candida-induced vaginitis, Candida albicans, non-albicans species, antimycotics, dose-dependent sensitivity

参考

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Genital candidiasis in the pattern of opportunistic vaginal infections. The principles of laboratory diagnosis and the value of monitoring of fungal susceptibility to antimycotics

全文:

详细

关键词

作者简介

A Ankirskaya

V Muravyeva

T Mironova

T Koroleva

L Lyubasovskaya

T Karapetyan

G Bairamova

参考

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